Anthony J. G. Hanley
Anthony HanleyPhD
Associate Professor
Department of Nutritional Sciences

Contact Info

T. (416) 978-3616
F. (416) 978-5882

Location

FitzGerald Building, Room 341
150 College Street
Toronto
ON, M5S 3E2

Research Interests

Nutritional and metabolic epidemiology of type 2 diabetes; Underlying phenotypes in high-risk populations.

Accepting

Pending the availability of funding

Degree/Qualifications

PhD Epidemiology, University of Toronto

Professional Memberships

Canadian Diabetes Association
American Diabetes Association

Research/Teaching

Graduate Students

Sheena Kayaniyil (PhD)
Sylvia Ley (PhD)
Jolynn Dickson (MSc)
Luke Johnston (MSc)
Christine Lee (postdoctoral fellow)

Publications and Awards

Recent Publications

Lee CC, Watkins SM, Lorenzo C, Wagenknecht LE, Il’yasova D, Chen YDI, Haffner SM, Hanley AJ.  Branched Chain Amino Acids and Insulin Metabolism – The Insulin Resistance Atherosclerosis Study (IRAS).  Diabetes Care 2016 Feb 19. pii: dc152284. [Epub ahead of print]

Dickson JC, Liese AD, Lorenzo C, Haffner SM, Wagenknecht LE, Hanley AJ. Associations of Coffee Consumption with Markers of Liver Injury in the Insulin Resistance Atherosclerosis Study (IRAS). BMC Gastroenterology 2015 Jul 28;15(1):88.

Mansuri S, Badawi A, Kayaniyil S, Cole DE, Harris SB, Mamekeesick M, Maguire J, Zinman B, Connelly PW, Hanley AJ. Associations of circulating 25(OH)D with cardiometabolic disorders underlying type 2 diabetes mellitus in an Aboriginal Canadian community. Diabetes Research and Clinical Practice 2015 Aug;109(2):440-9. Epub 2015 Apr 20.

Lee CC, Perkins BA, Kayaniyil S, Harris SB, Retnakaran R, Gerstein HC, Zinman B, Hanley AJ. Peripheral neuropathy and nerve dysfunction in individuals at high risk for type 2 diabetes - the PROMISE cohort. Diabetes Care 2015 May;38(5):793-800. Epub 2015 Feb 9. 

Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, Lorenzo C, Hanley AJ. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. American Journal of Clinical Nutrition 2014 Dec;100(6):1532-40 (epub ahead of print Oct 8 2014).

Lee CT, Harris SB, Retnakaran R, Gerstein HC, Perkins BA, Zinman B, Hanley AJ.  White blood cell subtypes, insulin resistance and β-cell dysfunction in high-risk individuals - the PROMISE cohort. Clin Endocrinol (Oxf). 2014 Oct;81(4):536-41. doi: 10.1111/cen.12390. Epub 2014 Jan 16.

Kakekagumick KE, Naqshbandi Hayward M, Harris SB, Saksvig B, Gittelsohn J, Manokeesic G, Goodman S, Hanley AJ. Sandy lake health and diabetes project: a community-based intervention targeting type 2 diabetes and its risk factors in a first nations community. Front Endocrinol (Lausanne). 2013 Nov 12;4:170. doi: 10.3389/fendo.2013.00170. eCollection 2013. PubMed PMID: 24302919; PubMed Central PMCID: PMC3824247.

Johnston LW, Harris SB, Retnakaran R, Gerstein HC, Zinman B, Hamilton J, Hanley AJ. Short leg length, a marker of early childhood deprivation, is associated with metabolic disorders underlying type 2 diabetes mellitus: The PROMISE cohort study. Diabetes Care 2013 Nov;36(11):3599-606. Epub 2013 Oct 2.

Ley SH, Hanley AJ, Sermer M, Zinman B, O'Connor DL. Lower dietary vitamin E intake during the second trimester is associated with insulin resistance and hyperglycemia later in pregnancy. Eur J Clin Nutr 2013 Nov;67(11):1154-6. doi: 10.1038/ejcn.2013.185. Epub 2013 Sep 25. PubMed PMID: 24065066.

Lee CT, Liese AD, Lorenzo C, Wagenknecht LE, Haffner SM, Rewers MJ, Hanley AJ. Egg consumption and insulin metabolism in the Insulin Resistance Atherosclerosis Study (IRAS). Public Health Nutr. 2013 Jun 19:1-8. [Epub ahead of print] PubMed PMID: 23777633.

Kayaniyil S, Harris SB, Retnakaran R, Vieth R, Knight JA, Gerstein HC, Perkins BA, Zinman B, Hanley AJ. Prospective association of 25(OH)D with metabolic syndrome. Clin Endocrinol (Oxf). 2014; Apr;80(4):502-7. 2013 Mar 2. doi: 10.1111/cen.12190. [Epub ahead of print] PubMed PMID: 23452164.

Lee CC, Haffner SM, Wagenknecht LE, Lorenzo C, Norris JM, Bergman RN, Stefanovski D, Anderson AM, Rotter JI, Goodarzi MO, Hanley AJ. Insulin Clearance and the Incidence of Type 2 Diabetes in Hispanics and African Americans: The IRAS Family Study. Diabetes Care. 2013 Apr;36(4):901-7 2012 Dec 5. [Epub ahead of print] PubMed PMID: 23223351.

Lee CC, Lorenzo C, Haffner SM, Wagenknecht LE, Goodarzi MO, Stefanovski D, Norris JM, Rewers MJ, Hanley AJ. Components of metabolic syndrome and 5-year change in insulin clearance - The Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Obes Metab. 2013 May;15(5):441-7. doi: 10.1111/dom.12049. Epub 2013 Jan 21.

Lee CC, Lorenzo C, Haffner SM, Wagenknecht LE, Festa A, Goodarzi MO, Stefanovski D, Olson NC, Norris JM, Rewers MJ, Hanley AJ. The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetologia. 2013 Jan;56(1):112-20. doi: 10.1007/s00125-012-2741-8. Epub 2012 Oct 10. PMID: 23052060

Ley SH, Harris SB, Connelly PW, Mamakeesick M, Gittelsohn J, Wolever TM, Hegele RA, Zinman B, Hanley AJ. Utility of non-high density lipoprotein cholesterol in assessing incident type 2 diabetes risk. Diabetes Obes Metab. 2012 Sep;14(9):821-5. Apr 17. doi: 10.1111/j.1463-1326.2012.01607.x. [Epub ahead of print] PubMed PMID:22510237.

Ley SH, Hanley AJ, Sermer M, Zinman B, O'Connor DL. Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk. Am J Clin Nutr. 2012 Apr;95(4):867-74. Epub 2012 Feb 29. PubMed PMID: 22378730.

Loopstra-Masters RC, Haffner SM, Lorenzo C, Wagenknecht LE, Hanley AJ.  Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetologia. 2011 Dec;54(12):3047-54. Epub 2011 Sep 30.

Ley SH, Hanley AJ, Retnakaran R, Sermer M, Zinman B, O'Connor DL. Effect of macronutrient intake during the second trimester on glucose metabolism later in pregnancy. Am J Clin Nutr. 2011 Nov;94(5):1232-40. Epub 2011 Sep 28.

Kayaniyil S, Retnakaran R, Harris SB, Vieth R, Knight JA, Gerstein HC, Perkins BA, Zinman B, Hanley AJ. Prospective Associations of Vitamin D with Beta-Cell Function and Glycemia: the PROMISE (PROspective Metabolism and ISlet cell Evaluation) Cohort Study. (Diabetes, 2011 Nov;60(11):2947-53. Epub 2011 Sep 12.).

Loopstra-Masters RC, Liese AD, Haffner SM, Wagenknecht LE, Hanley AJ.  Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia. 2011 Feb;54(2):320-8. Epub 2010 Nov 3.

Ley SH, O'Connor DL, Retnakaran R, Hamilton JK, Sermer M, Zinman B, Hanley AJ.  Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design. BMC Public Health. 2010 Oct 6;10:590. PubMed PMID: 20925937; PubMed Central PMCID: PMC2965719.

Kayaniyil S, Vieth R, Harris SB, Retnakaran R, Knight JA, Gerstein HC, Perkins BA, Zinman B, Hanley AJ.  Association of 25(OH)D and PTH with metabolic syndrome and its traditional and non-traditional components. Journal of Clinical Endocrinology and Metabolism, 2011 Jan;96(1):168–175. Epub 2010 Oct 27.

Ley SH, Harris SB, Mamakeesick M, Noon T, Fiddler E, Gittelsohn J, Wolever TM, Zinman B, Hanley AJ.  Metabolic syndrome and its components identify Aboriginal Canadians at high risk of developing type 2 diabetes.  CMAJ 2009 Mar 17;180(6):617-24.

Honours and Awards

Tier II Canada Research Chair in the Epidemiology of Type 2 Diabetes

Early Researcher Award, Ontario Ministry of Research and Innovation

Continuing Excellence in Graduate Teaching & Mentorship, Faculty of Medicine, University of Toronto

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