AcceptingPending the availability of funding
The ultimate goal of our research team is to elucidate the potential of diet to prevent and treat chronic diseases, primarily heart disease, cancer, and diabetes. Our research is clinically based. Dietary trials allow us to also assess mechanisms in vivo by which diet and/or its components alter risk for disease. We have spent considerable time assessing the glycemic index of foods, and have identified legumes and traditional methods of processing as producing a low-glycemic index (e.g., white pasta - low vs. white bread - high). We have and continue to carry out research on vegetable proteins and their potential health benefits (e.g., soy, gluten, and other cereal and vegan proteins). Most recently we have started to combine foods with cholesterol lowering actions (soy, viscous fibers, oats, barley, plant sterols and nuts - almonds) in a single diet to lower serum cholesterol, what we have termed as “dietary portfolio.”
We have demonstrated that early statin-like effects can be achieved under highly controlled conditions. In the real world this dietary approach has a somewhat dampened level of efficacy, but remains a highly effective dietary approach to cholesterol reduction. We continue to carry out studies on low-glycemic index diets, and the quest to find new low-glycemic index foods continues. We also work in collaboration with the food industry on a diverse spectrum of food products and food components ranging from macronutrients to phytochemicals.
With the support of the Institute of Nutrition, Metabolism and Diabetes (INMD) of Canadian Institute of Health Research (CIHR) we are establishing a Nutrition Trialists Network (NTN) to carry out major diet trials nationally and internationally and to link with exercise experts and trialists to form a comprehensive lifestyle program for the prevention and treatment of CVD, Diabetes and other chronic disease.
We are also putting together a Chronic Disease and Clinical Trail Centre at the UofT to link with the Centre for Child Nutrition and Health (CCNH) in the Nutritional Sciences department.
Publications and Awards
Jenkins, DJA. Jones PJ. Frohlich J. Lamarche B. Ireland C. Nishi SK. Srichaikul K. Galange P. Pellini C. Faulkner D. de Souza RJ. Sievenpiper JL. Mirrahimi A. Jayalath VH. Augustin LS. Bashyam B. Leiter LA. Josse R. Couture P. Ramprasath V. Kendall CW. The effect of a dietary portfolio compared to a DASH-type diet on blood pressure. Nutrition Metabolism and Cardiovascular Diseases. 25(12):1132-9, 2015 Dec.
Jenkins, DJA. Jones PJ. Lamarche B. Kendall CW. Faulkner D. Cermakova L. Gigleux I. Ramprasath V. de Souza R. Ireland C. Patel D. Srichaikul K. Abdulnour S. Bashyam B. Collier C. Hoshizaki S. Josse RG. Leiter LA. Connelly PW. Frohlich J. Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial. JAMA. 306(8):831-9, 2011 Aug.
Jenkins, DJA. Kendall CWC. Faulkner DA. Nguyen T. Kemp T. Marchie A. Wong JM. de Souza R. Emam A. Vidgen E. Trautwein EA. Lapsley KG. Holmes C. Josse RG. Leiter LA. Connelly PW. Singer W. Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. American Journal of Clinical Nutrition. 83(3):582-91, 2006 Mar.
Jenkins, DJA. Kendall CWC. Marchie A. Faulkner DA. Wong JMW. De Souza R. Emam A. Parker TL. Vidgen E. Trautwein EA. Lapsley KG. Josse RG. Leiter LA. Singer W. Connelly PW. Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. American Journal of Clinical Nutrition. Vol. 81(2)(pp 380-387), 2005.
Jenkins, DJA. Kendall CWC. Marchie A. Faulkner DA. Josse AR. Wong JMW. de Souza R. Emam A. Parker TL. Li TJ. Josse RG. Leiter LA. Singer W. Connelly PW. Direct comparison of dietary portfolio vs statin on C-reactive protein. European Journal of Clinical Nutrition. Vol. 59(7)(pp 851-860), 2005.
Jenkins, DJA. Kendall CW. Marchie A. Faulkner DA. Wong JM. de Souza R. Emam A. Parker TL. Vidgen E. Lapsley KG. Trautwein EA. Josse RG. Leiter LA. Connelly PW. Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA. 290(4):502-10, 2003 Jul 23.
Jenkins, DJA. Kendall CW. D'Costa MA. Jackson CJ. Vidgen E. Singer W. Silverman JA. Koumbridis G. Honey J. Rao AV. Fleshner N. Klotz L. Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. Journal of Urology. 169(2):507-11, 2003 Feb.
Jenkins, DJA. Kendall CW. Marchie A. Parker TL. Connelly PW. Qian W. Haight JS. Faulkner D. Vidgen E. Lapsley KG. Spiller GA. Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial. Circulation. 106(11):1327-32, 2002 Sep 10.
Jenkins, DJA. Kendall CWC. Augustin LSA. Martini MC. Axelsen M. Faulkner D. Vidgen E. Parker T. Lau H. Connelly PW. Teitel J. Singer W. Vandenbroucke AC. Leiter LA. Josse RG. Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes. Diabetes Care. Vol. 25(9)(pp 1522-1528), 2002.
Jenkins, DJA. Kendall CW. Jackson CJ. Connelly PW. Parker T. Faulkner D. Vidgen E. Cunnane SC. Leiter LA. Josse RG. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. American Journal of Clinical Nutrition. 76(2):365-72, 2002 Aug.
Jenkins, DJA. Kendall CW. Connelly PW. Jackson CJ. Parker T. Faulkner D. Vidgen E. Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women. Metabolism: Clinical & Experimental. 51(7):919-24, 2002 Jul.
Jenkins, DJA. Kendall CW. Vuksan V. Vidgen E. Parker T. Faulkner D. Mehling CC. Garsetti M. Testolin G. Cunnane SC. Ryan MA. Corey PN. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. American Journal of Clinical Nutrition. 75(5):834-9, 2002 May.