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My research program focuses on (i) the pathophysiologic mechanisms of metabolic risk related to weight gain in children; (ii) evaluating biologic and psychosocial determinants of weight regulation and response to obesity treatment. I am the medical director of the SickKids Team Obesity Management Program (STOMP), a research and clinical program for children and adolescents with severe obesity. I have examined insulin resistance and pancreatic beta cell function and the metabolic complications of obesity in childhood in children with endocrine conditions, such as those with hypothalamic obesity, and adolescents with type 1 and 2 diabetes. I am lead investigator on the pediatric arm of an ongoing cohort study to examine very early determinants of metabolic risk in children born to women with gestational diabetes.
Publications and Awards
Koltin D, O’Gorman CS, Murphy A, Ngan B, Daneman A, Navarro OM, García C, Atenafu EG, Wasserman JD, Hamilton JK, Rachmiel M. Pediatric thyroid nodules: Ultrasonographic characteristics and inter-observer variability in prediction of malignancy. Journal of Pediatric Endocrinology and Metabolism. In press. Co-Author.
Anderson LN, Lebovic G, Hamilton JK, Hanley AJ, McCrindle BW, Maguire JL, Parkin PC, Birken CS, on behalf of the TARGet Kids Collaboration*. Body mass index, waist circumference, and the clustering of cardiometabolic risk factors in early childhood. Paediatric and Perinatal Epidemiology 2016: 30 (2): pp 160-170. Co-Author.
Kramer CK, Hamilton JK, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R. Differential impact of maternal and paternal ethnicity on the pattern of fat distribution in infants at age 3 months. Pediatric Obesity 2016: 11 (1): pp 11-17. Co-Principal Author.
Hadjiyannakis S, Buchholz A, Chanoine JP, Jetha MM, Gaboury L, Hamilton JK, Birken C, Morrison KM, Legault L, Bridger T, Cook S, Lyons J, Sharma AM, Ball GDC. The Edmonton Obesity Staging System for Pediatrics (EOSS-P): A proposed clinical staging system for pediatric obesity. Paediatrics & Child Health 2016: 21 (1): pp 21-26. Co-Author.
Wells GD, Banks L, Thompson S, Caterini J, Noseworthy M, Rayner T, Syme C, McCrindle BW, Hamilton JK. The association among skeletal muscle phosphocreatine recovery, adiposity, and insulin resistance in children. In press. Senior Responsible Author.
Sellers EAC, Hadjiyannakis S, Amed S, Dart A, Dyck R, Hamilton JK, Langois V, Panagiotopoulos C, Ugnat AM, Dean HJ. Persistent albuminuria in children with type 2 diabetes: a Canadian paediatric surveillance program study. The Journal of Pediatrics 2016: 168: pp 112-117. Co-Author.
Xie RH, Liu YJ, Retnakaran R, MacFarlane AJ, Hamilton JK, Smith G, Walker MC, Wen SW. Maternal folate status and obesity/insulin resistance in the offspring: a systematic review. International Journal of Obesity 2016: 4D (1): pp 1-9. Co-Author.
Coles N, Bremer K, Kives S, Hamilton JK. Utility of the oral glucose tolerance test to assess glucose abnormalities in adolescents with polycystic ovarian syndrome. Journal of Pediatric and Adolescent Gynecology 2016: 29 (1): pp 48-52. Senior Responsible Author.
Gurnani M, Birken C, Hamilton JK. Childhood obesity: causes, consequences and management. Pediatric Clinics of North America 2015: 62 (4): pp 821-840. Senior Responsible Author.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton JK, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015: 25 (7): pp 716-759. Co-Author.
Yeshayahu Y, Koltin D, Hamilton JK, Nathan PC, Urbach S. Medication-induced diabetes during induction treatment for ALL, an early marker for future metabolic risk? Pediatric Diabetes 2015: 16 (2): pp 104-108. Co-Author.
Levitan R, Rivera J, Silveira P, Steiner M, Gaudreau H, Hamilton JK, Kennedy J, Davis C, Dube L, Fellows L, Wazana A, Matthews S, Meaney M. Gender differences in the association between stop-signal reaction times, body mass indices and/or spontaneous food intake in preschool children: an early model of compromised inhibitory control and obesity. International Journal of Obesity (London) 2015: 39 (4): pp 614-619. Co-Author.
Cohen M, Harrington J, Narang I, Hamilton JK. Growth hormone secretion decreases with age in pediatric Prader-Willi Syndrome. Clinical Endocrinology (Oxford) 2015: 83 (2): pp 212-215. Senior Responsible Author.
West S, O’Gorman CS, Elzibak AH, Caterini J, Noseworthy MD, Rayner T, Hamilton JK, Wells GD. Skeletal muscle microvascular function in girls with Turner Syndrome. BBA Clinical 2015: 3 (1): pp 25-30. Co-Senior Responsible Author.
Schwartz A, Anderson GH, Patel BP, Vien S, McCrindle BW, Hamilton JK. Acute decrease in serum testosterone after a mixed glucose and protein beverage in obese peripubertal boys. Clinical Endocrinology 2015: 83 (3): pp 332-338. Senior Responsible Author.
Vali R, Rachmiel M, Hamilton JK, El Zein M, Costantini D, Daneman A, Charron M. The role of ultrasound in the follow-up of children with differentiated thyroid cancer. Pediatric Radiology 2015: 45 (7): pp 1039-1045. Co-Author.
Luca P, Dettmer E, Khoury M, Grewal P, Manlhiot C, McCrindle BW, Birken C, Hamilton JK. Adolescents with severe obesity: outcomes of participation in an intensive obesity management program. Pediatric Obesity 2015: 10 (4): pp 275-282. Senior Responsible Author.