Johane AllardMD, FRCPC
Professor
Departments of Medicine and Nutritional Sciences

Contact Info

T. (416) 340-5159

Location

Toronto General Hospital
585 University Avenue Suite 9N-973
Toronto
ON, M5G 2C4

Research Interests

Nutrition and gastrointestinal disorders.

Accepting

None

Degree/Qualifications

Fellow of the Royal College of Physicians of Canada, Gastroenterology / Certificat de spécialité de la province de Québec, Gastroenterology
Certificat de spécialité de la province de Québec, Internal Medicine / Fellow of the Royal College of Physicians of Canada, Internal Medicine
Federation Licensure Examination (FLEX), New York State
DrMed, University of Montreal / Licentiate of the Medical Council of Canada

Professional Memberships

Johane P. Allard is a professor of medicine at the University of Toronto, Canada, and is cross-appointed with the Department of Nutritional Sciences. She trained in gastroenterology at McGill University before completing a research fellowship, funded by the National Institute of Nutrition, at the University of Toronto.

Professional Memberships:

Editorial Boards  

2005               Editorial Board, Canadian Journal of Gastroenterology

2004-07         Editor, Lecture Series in Clinical Nutrition on CD-ROM    

2003-04         Editor, Canadian Society for Clinical Nutrition Newsletter & Journal Review    

2001               Editorial Reviewer, Journal of Geriatric Care

2001-04         Editor, Clinical Nutrition Rounds

1996-2000     Co-Editor, Current Opinion in Clinical Nutrition and Metabolic Care      
 

Professional and Honorary Societies

2005               Member, Dr. F. M. Hill Advisory Board Trust Fund, Women’s College

                       Member, Crohn’s and Colitis Foundation of Canada

                       Member, Canadian Liver Foundation

                       Member, American College of Gastroenterology

2002-04          Director, Governing Board, Canadian Digestive Diseases Foundation

2001-04          Founder & President, Canadian Society for Clinical Nutrition

1997                Société francophone de nutrition parentérale et entérale

1994-96          Advisory Committee, Speciality Food Shop, Hospital for Sick Children

1994                Scientific Advisory Council, National Institute of Nutrition

1993-96          The Medicine Group (Canada) Limited

1991                Scientific Board, National Institutes of Health (NIH)

                        American Gastroenterological Association (AGA)

                        Canadian Association of Gastroenterology (CAG)

                        Ontario and Canadian Medical Associations (OCMA)

                        American Society of Clinical Nutrition (ASCN)

1991-96           Advisory Board, Clintec & Ross  

1990                 American Society of Parenteral and Enteral Nutrition (ASPEN)

1990-2001       American College of Nutrition (ACN)

Grant Review Committees    

2006                 Canadian Foundation for AIDS Research

2000                 National Institute of Health

2001-04           Canadian Association of Gastroenterology

1996-99           Crohn’s and Colitis Foundation of Canada

National Committees

2010                 Advisory Board, Canadian Nutrition Society

2009                 Chair, Canadian Malnutrition Task Force

2008                 Vice-Chair, GI Examination Board Royal College of Physicians and Surgeons of Canada

2006                 Member, GI Examination Board, Royal College of Physician and Surgeons of Canada

2005                 Chair, Canadian Home Total Parenteral Nutrition Registry

2000-10           Advisory Board, Canadian Society for Clinical Nutrition

1996-99           Crohn’s and Colitis Foundation of Canada

University Committees

2006                 Department Division Director Committee, University of Toronto

2005                 Faculty Development Committee

2005-07           Chair, Gender Issues Committee, Medicine, University of Toronto

2003-07           Gender Issues Committee, Medicine, University of Toronto

1999-2001       Search Committee for Chief of Gastro-intestinal Diseases, UHN Toronto

1994-96           Faculty Advisory Committee on Animal Services, University of Toronto

1985-86           Training Committee, McGill University, Montreal

1982-83           Intensive Care Unit of Teaching Committee, Maisonneuve-Rosemont Hospital, Montreal

                         Executive Board, Maisonneuve‑Rosemont Hospital, Montreal

Hospital Committees

2002                 Member, Senior Advisory Committee, UHN

                         Member, Economics Committee, UHN

1998                 Member, Awards Committee, Institute of Medical Science, U of T

1990                 Director, the Nutrition Program, Toronto General Hospital

                          Chair, the Nutrition Review Committee

2002-07            Chair, Women’s Issues Committee, UHN/MSH

1995-97            Section Chief, Luminal Division, Toronto Hospital

1994-99            Toronto Hospital Economics Committee

1994-97            GI Training Program Committee

Pharmaceutics and Therapeutics Committee

1989-90            Nutrition Committee, Toronto Hospital

Research/Teaching

Research Synopsis:

Gut microbiome in bariatric care
Many people who are severely obese have high blood sugar levels and type 2 diabetes. Both obesity and type 2 diabetes are growing health problems in Canada. The only reliable and effective treatment for severe obesity is weight loss surgery, which also remarkably improves type 2 diabetes and blood sugar control, even before weight loss occurs. New studies show that changes in the gut bacteria can play an important role in this process. The purpose of this project is to examine the gut bacteria of patients undergoing bariatric surgery in order to clarify their role in improvements of blood sugar control.

Non-alcoholic fatty liver disease and nutrition-related factors that could contribute to the pathogenesis, including:

  • Diet and lifestyle (dietary intake, obesity, physical activity)
  • Oxidative stress and antioxidants
  • Lipid profile of liver and other tissues (lipid classes, fatty acid composition)
  • Hepatic gene expression (genes related to oxidative stress, lipid metabolism, insulin resistance)
  • Intestinal microbiota

Home Parenteral Nutrition
Dr. Allard's team is managing the Canadian Home Total Parenteral Nutrition (TPN) Registry, which collects demographic information, medical history, and health status of patients in Home TPN programs across Canada. Dr. Allard’s team is also conducting a multicentre, randomized, controlled trial to examine the effects of fish-oil based lipid emulsion on parenteral nutrition-associated liver disease. Dr. Allard's areas of expertise also include inflammatory bowel disease, celiac disease, and short bowel syndrome. In addition, she and her team have conducted studies on patients with HIV infection or chronic Hepatitis C infection, as well as lung and liver transplant patients.

Nutrition Care in Canadian Hospitals
Dr Allard is one of the co-chairs of the recently founded Canadian Malnutrition Task Force (http://nutritioncareinca>nada.ca/). The aim of the task force is to create a knowledge base and close the gaps between research and practice in the prevention, detection, and treatment of malnutrition in Canadians through the continuum of care. Their first study ‘Nutrition Care in Canadian Hospitals’ is currently conducted at multiple hospitals across Canada, including the University Health Network with Dr. Allard as a site investigator. Dr. Allard's areas of expertise also include inflammatory bowel disease, celiac disease, and short bowel syndrome. In addition, she and her team have conducted studies on patients with HIV infection or chronic hepatitis C infection, as well as lung and liver transplant patients.

Recent Theses/Graduate Projects Supervised

"Role of intestinal microbiota, endotoxin, and short-chain fatty acids in non-alcoholic fatty liver disease"
Hannah Da Silva, MSc student, Nutritional Sciences, University of Toronto.
"Short-chain fatty acids & intestinal microbiota in morbidly obese patients: A comparison between simple steatosis & non-alcoholic steatohepatitis"
Katherine Schwenger, MSc student, Medical Sciences, University of Toronto.
"Intralipid vs. ClinOleic: Comparison of two intravenous lipid emulsions among hospitalized patients receiving parenteral nutrition"
Sultan Alenezi, PhD student, Nutritional Sciences, University of Toronto.

Publications and Awards

Recent Publications

Arendt BM, Comelli EM, Ma DW, Lou W, Teterina A, Kim T, Fung SK, Wong DK, McGilvray I, Fischer SE, Allard JP. Altered hepatic gene expression in non-alcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids. Hepatology. 2015 Jan 10. doi: 10.1002/hep.27695. [Epub ahead of print]

Allard JP, Keller H, Jeejeebhoy KN, Laporte M, Duerksen D, Gramlich L, Payette H, Bernier P, Vesnaver E, Davidson B, Teterina A, Lou W. Malnutrition at hospital admission: contributors and impact on length of stay. A prospective cohort study from the Canadian Malnutrition Task Force. JPEN J Parenter Enteral Nutr. 2015 Jan 26. pii: 0148607114567902. [Epub ahead of print].

Allard JP, Keller H, Jeejeebhoy KN, Laporte M, Duerksen D, Gramlich L, Payette H, Bernier P, Davidson B, Teterina A, Lou W. Decline in nutritional status is associated with prolonged length of stay in hospitalized patients admitted for 7 days or more: a prospective cohort study. Clin Nutr. 2015 Jan 21 doi: 10.1016/j.clnu.2015.01.009. [Epub ahead of print]

Duerksen DR, Keller HH, Vesnaver E, Laporte M, Jeejeebhoy KN, Payetter H, Gramlich L, Bernier P, Allard JP. Nurses' perceptions regarding the prevalence, detection and causes of malnutrition in Canadian hospitals: results of a Canadian Malnutrition Task Force Survey. JPEN J Parenter Enteral Nutr. 2014 Sep 4. pii: 0148607114548227. [Epub ahead of print]

Keller H, Allard JP, Laporte M, Davidson B, Payette H, Bernier P, Jeejeebhoy K, Duerksen DR, Gramlich L. Predictors of dietitian consult on medical and surgical wards. Clin Nutr. 2014 Nov 29. pii: S0261-5614(14)00292-1. doi: 10.1016/j.clnu.2014.11.011. [Epub ahead of print].

Mouzaki M, Comelli EM, Arendt BM, Bonengel J, Fung SK, Fischer S, McGilvray ID, Allard JP. Intestinal Microbiota in Patients with Non-Alcoholic Fatty Liver Disease. Hepatology 2013 Jul; 58(1):120-7. doi: 10.1002/hep.26319. [Epub 2013 May 14].

Da Silva H, Arendt BM, Noureldin SA, Therapondos G, Guindi M, Allard JP. A Cross-Sectional Study Assessing Dietary Intake and Physical Activity in Canadian Patients with Non-Alcoholic Fatty Liver Disease versus Healthy Controls. J Acad Nutr Diet. 2014; 114(8):1181-1194. pii: S2212-2672(14)00099-9. doi: 10.1016/j.jand.2014.01.009. [Epub 2014 Mar 14]

Schwenger KJP, Allard JP. Clinical approaches to non-alcoholic fatty liver disease. (Review) World J Gastroenterol. 2014 Feb; 20(7):1712–23. doi: 10.3748/wjg.v20.i7.1712.

Duerksen DR, Keller HH, Vesnaver E, Allard JP, Bernier P, Gramlich L, Payette H, Laporte M, Jeejeebhoy K. Physicians' Perceptions Regarding the Detection and Management of Malnutrition in Canadian Hospitals: Results of a Canadian Malnutrition Task Force Survey. JPEN J Parenter Enteral Nutr. 2014 Jun 2. pii: 0148607114534731. [Epub ahead of print]

O'Keefe SJ, Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B. Safety and Efficacy of Teduglutide After 52 Weeks of Treatment in Patients with Short Bowel Syndrome Intestinal Failure. Clin Gastroenterol Hepatol. 2013 Jul; 11(7):815-23.e1-3. doi: 10.1016/j.cgh.2012.12.029. [Epub 2013 Jan 17]

Arendt BM, Ma DWL, Simons B, Noureldin S, Therapondos G, Guindi M, Sherman M, Allard JP. Non-alcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. Appl Physiol Nutr Metabolism 2013 Mar; 38(3):334-40. doi: 10.1139/apnm-2012-0261. [Epub 2012 Oct 15].

Fernandes G, Kaila B, Jeejeebhoy K, Gramlich LM, Armstrong D, Allard JP. Canadian Home Total Parenteral Nutrition (HTPN) Registry: Validation and Patient Outcomes. JPEN 2012; 36(4):407-14. doi: 10.1177/0148607111434599 [Epub 2012 Feb 10].

Mouzaki M, Allard J. Non-alcoholic steatohepatitis: the therapeutic challenge of a global epidemic. Ann Gastroenterol. 2012; 25(2): 207-217.

Honours and Awards

2010      Supervised PhD Student, Arcand JoAnne – Nestle Nutrition Graduate Student Award

2003      Best Abstract Award, Canadian Society for Clinical Nutrition 2003

1993      Best Paper, National Colon-Proctology Meeting, Brazil (Supervised recipient Helio Plapler)

1997      Best Paper, CAG Fellowship course (Supervised recipient Helena Lau)

1995      ASPEN: Harry Vars Award (Supervised recipient Albert Verhage)

1990-91  Outstanding Clinical Teacher Award (Joint Undergraduate Medicine & Surgery Education Committee),                                          
                 the Toronto Hospital

1990       Dean’s Fund

1986-89   National Institute of Nutrition Fellowship Award

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