Michael ArcherPhD
Professor Emeritus
Departments of Nutritional Sciences and Medical Biophysics

Contact Info

F. (416) 978-5882

Location

150 College Street
Toronto
ON, M5S 3E2

Research Interests

Role of dietary factors and susceptibility genes in cancer development.

Accepting

Not accepting new students

Degree/Qualifications

1989 DSc, University of Warwick
1970 PhD, University of Toronto, in Biochemistry
1967 MSc, University of Warwick, in Molecular Enzymology
1965 MA, University of Cambridge, in Chemistry

Professional Memberships

American Association for Cancer Research
American Society for Nutrition
Canadian Society for Nutritional Sciences
Society of Toxicology
Society of Toxicology of Canada

Research/Teaching

Graduate Students

Kathryn Hopperton

Publications and Awards

Recent Publications

Archer, M.C. Role of Sp transcription factors in the regulation of cancer cell metabolism. Genes and Cancer, 2, 712-719, 2011.

Li, Y-J., Liu, G., Li, Y., Vecchiarelli-Federico, L.M., Liu, J.C., Zacksenhaus, E., Shan, S.W., Yang, B.B., Li, Q., Dash, R., Fisher, P.B., Ben-David, Y. and Archer, M.C. mda-7/IL-24 expression inhibits breast cancer through up-regulation of growth arrest-specific gene 3 (gas3) and disruption of  β1 integrin function. Mol. Cancer Res., 11, 593-603, 2013.

Hopperton, K.E., Duncan, R.E., Bazinet, R.P., and Archer, M.C. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Exp. Cell Res., 320, 302-310, 2014.

Menezes, M., Shen, X-N., Das, S., Emdad, L., Guo, C., Yuan, F., Li, Y-J., Archer, M.C., Zacksenhaus, E., Windle, J., Subler, M., Ben-David, Y., Sarkar, D., Wang, X-Y. and  Fisher, P.B. MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic models of breast cancer. Oncotarget, 6, 36928-42, 2015.

Li, Y-J., Liu, G., Xia, L., Xiao, X., Liu, J.C., Menezes, M.E., Das, S.K., Emdad, L., Sarkar, D., Fisher, P.B., Archer, M.C., Zacksenhaus, E. and Ben-David, Y. Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic mice. Oncotarget, 6, 36943-54, 2015.

Yang, K., Fard, S., Furrer, R., Archer, M.C., Bruce, W.R., Lip, H.Y., Mehta, R., O’Brien, P.J., Giacca, A., and Ward, W.E. Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: preliminary findings. Nutrition and Cancer, 68, 94-104, 2016.

Honours and Awards

1994-04         Natural Sciences and Engineering Research Council Research Chair in Nutritional Toxicology

1974               Future Leader Award, International Life Sciences Institute (ILSI)

1977-82         National Institutes of Health Research Career Development Award

1977               Fellow of the Royal Society of Chemistry (London)

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