Richard BazinetPhD
Associate Professor
Department of Nutritional Sciences

Contact Info

T. (416) 946-8276
F. (416) 978-5882

Location

FitzGerald Building, Room 306
150 College Street
Toronto
ON, M5S 3E2

Research Interests

The regulation and role of brain lipid metabolism in neurodegenerative diseases and neuropsychiatric disorders.

Accepting

Pending the availability of funding

Degree/Qualifications

Postdoctoral Fellowship, Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health
PhD, University of Toronto
BSc, University of Western Ontario

Professional Memberships

American Society for Neurochemistry
American Oil Chemists’ Society
Canadian Nutrition Society
International Society for the Study of Fatty Acids and Lipids (president elect)

Research/Teaching

Research Synopsis:

The overall goal of my research program is to identify the mechanisms that regulate brain lipid metabolism (signaling) and to identify the role of brain lipid metabolism in the pathogenesis of neurodegenerative diseases and neuropsychiatric disorders. We are currently taking a kinetic and biochemical approach to studying the mechanisms by which dietary polyunsaturated fatty acids regulate the metabolism of arachidonic and docosahexaenoic acids within brain phospholipids. We are also investigating the role of dietary polyunsaturated fatty acids in rodent models of neuroinflammation and Alzheimer's disease.                                           

Publications and Awards

Recent Publications

Trepanier MO, Kopperton KE, Mizrahi R, Mechawar N, Bazinet RP.  Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review.  Mol Psychiatry.  In press. doi:10.1038/mp.2016.83

Metherel AH, Domenichiello AF, Kitson AP, Hopperton KE, Bazinet RP. Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat.  Biochim Biophys Acta. 2016 Jun 2. pii: S1388-1981(16)30152-4

Johnston LW, Harris SB, Retnakaran R, Zinman B, Giacca A, Liu Z, Bazinet RP, Hanley AJ.  Longitudinal Associations of Phospholipid and Cholesteryl Ester Fatty Acids With Disorders Underlying Diabetes. J Clin Endocrinol Metab. 2016 Jun;101(6):2536-44

Kitson AP, Metherel AH, Chen CT, Domenichiello AF, Trépanier MO, Berger A, Bazinet RP. Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion.  J Nutr Biochem. 2016 Jul;33:91-102.

Domenichiello AF, Kitson AP, Chen CT, Trepanier MO, Stavro PM, Bazinet RP. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. J Nutr Biochem [in press]

Alashmali SM, Hopperton KE, Bazinet RP. Lowering dietary n-6 polyunsaturated fatty acids: interaction with brain arachidonic and docosahexaenoic acids.  Curr Opin Lipidol. 2016 Feb;27(1):54-66

Kubant R, Poon AN, Sánchez-Hernández D, Domenichiello AF, Huot PS, Pannia E, Cho CE, Hunschede S, Bazinet RP, Anderson GH.  A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats.  Nutr Diabetes. 2015 Dec 14

Viguiliouk E, Stewart SE, Jayalath VH, Ng AP, Mirrahimi A, de Souza RJ, Hanley AJ, Bazinet RP, Blanco Mejia S, Leiter LA, Josse RG, Kendall CW, Jenkins DJ, Sievenpiper JL. Effect of Replacing Animal Protein with Plant Protein on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2015 Dec 1;7(12):9804-24

Chen CT, Kitson AP, Hopperton KE, Domenichiello AF, Trépanier MO, Lin LE, Ermini L, Post M, Thies F, Bazinet RP. Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain.  Sci Rep. 2015 Oct 29;5:15791

Sánchez-Hernández D, Poon AN, Kubant R, Kim H, Huot PS, Cho CE, Pannia E, Reza-López SA, Pausova Z, Bazinet RP, Anderson GH. High vitamin A intake during pregnancy modifies dopaminergic reward system and decreases preference for sucrose in Wistar rat offspring. J Nutr Biochem. 2016 Jan;27:104-11.

Trepanier MO, Kwong KM, Domenichiello AF, Chen CT, Bazinet RP, Burnham WM. Intravenous infusion of docosahexaenoic acid increases serum concentrations in a dose-dependent manner and increases seizure latency in the maximal PTZ model. Epilepsy & Behavior.  2015 Sep;50:71-6.

Trepanier MO, Hopperton KE, Orr SK, Bazinet RP. N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update. European Journal of Pharmacology. 2015 May 30. pii: S0014-2999(15)30043-

Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP, Heit B, Bilan PJ, Lee WL, Klip A. Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promotes monocyte adhesion and impairs insulin transcytosis. Am J Physiol Endocrinol Metab. 2015 Jul 1;309(1):E35-44

Domenichiello AF, Kitson AP, Bazinet RP. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? Prog Lipid Res. 2015 Jul;59:54-66.

Cho CE, Pannia E, Huot PS, Sánchez-Hernández D, Kubant R, Dodington DW, Ward WE, Bazinet RP, Anderson GH. Methyl vitamins contribute to obesogenic effects of a high multivitamin gestational diet and epigenetic alterations in hypothalamic feeding pathways in Wistar rat offspring. Mol Nutr Food Res. 2015 Mar;59(3):476-89

Lin LE, Chen CT, Hildebrand KD, Liu Z, Hopperton KE, Bazinet RP. Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids.  J Lipid Res. 2015 Feb;56(2):390-402

Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease.  Nature Reviews Neuroscience. 2014 Dec;15(12):771-85

Parrott MD, Winocur G, Bazinet RP, Ma DW, Greenwood CE. Whole-food diet worsened cognitive dysfunction in an Alzheimer's disease mouse model. Neurobiol Aging. 2015 Jan;36(1):90-9.

Nishi S, Kendall CW, Gascoyne AM, Bazinet RP, Bashyam B, Lapsley KG, Augustin LS, Sievenpiper JL, Jenkins DJ. Effect of almond consumption on the serum fatty acid profile: a dose-response study.  British Journal of Nutrition.  2014 Oct 14;112(7):1137-46

Chen CT, Bazinet RP.  β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels.  Prostaglandins Leukot Essent Fatty Acids. 2015 Jan;92:33-40

Nishi SK, Kendall CW, Bazinet RP, Bashyam B, Ireland CA, Augustin LS, Blanco Mejia S, Sievenpiper JL, Jenkins DJ. Nut consumption, serum fatty acid profile and estimated coronary heart disease risk in type 2 diabetes.  Nutr Metab Cardiovasc Dis. 2014 Aug;24(8):845-52

Mason JK, Kharotia S, Wiggins AK, Kitson AP, Chen J, Bazinet RP, Thompson LU.  17β-estradiol increases liver and serum docosahexaenoic acid in mice fed varying levels of α-linolenic acid.  Lipids. 2014 Aug;49(8):745-56.

Ha V,  Sievenpiper JL, de Souza RJ, Jayalath VH, Mirrahimi A, Agarwal A, Chiavaroli L, Mejia SB, Sacks FM, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM, Vuksan V, Bazinet RP, Josse RG, Beyene J, Kendall CW, Jenkins DJ. Effect of dietary intake of pulses on established therapeutic lipid targets for cardiovascular risk reduction: a meta-analysis of randomized controlled trials. CMAJ. 2014 May 13;186(8):E252-62

Trépanier MO, Lim J, Lai TK, Cho HJ, Domenichiello AF, Chen CT, Taha AY, Bazinet RP, Burnham WM. Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model. Epilepsy Behav. 2014 Mar 21;33C:138-143.

Chen CT, Trépanier MO, Hopperton KE, Domenichiello AF, Masoodi M, Bazinet RP.  Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain. J Cereb Blood Flow Metab. 2014 Mar;34(3):376-9

Bazinet RP, Chu MW. Omega-6 polyunsaturated fatty acids: Is a broad cholesterol-lowering health claim appropriate? CMAJ. 2014 Apr 1;186(6):434-9

Francis BM, Yang J, Song BJ, Gupta S, Maj M, Bazinet RP, Robinson B, Mount HT. Reduced Levels of Mitochondrial Complex I Subunit NDUFB8 and Linked Complex I + III Oxidoreductase Activity in the TgCRND8 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2014;39(2):347-55

Domenichiello AF, Chen CT, Trepanier MO, Stavro PM, Bazinet RP.  Whole body synthesis rates of docosahexaenoic acid (DHA) from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. J Lipid Res. 2014 Jan;55(1):62-74

Hopperton KE, Duncan RE, Bazinet RP, Archer MC. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Exp Cell Res. 2014 Jan 15;320(2):302-10

Taha AY, Zahid T, Epps T, Trepanier MO, Burnham WM, Bazinet RP, Zhang L. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17.

Orr SK, Palumbo S, Bosetti F, Mount HT, Kang JX, Greenwood CE, Ma DW, Serhan CN, Bazinet RP.  Unesterified docosahexaenoic acid is protective in neuroinflammation.  J Neurochem. 2013 Nov;127(3):378-93.

 Chen CT, Domenichiello AF, Trepanier MO, Liu Z, Masoodi M, Bazinet RP. The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms.  J Lipid Res. 2013 Sep;54(9):2410-22.

Taha AY, Trepanier MO, Ciobanu FA, Taha NM, Ahmed M, Zeng Q, Cheuk WI, Ip B, Filo E, Scott BW, Burnham WM, Bazinet RP. A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats - implications for treating complex partial seizures. Epilepsy Behav. 2013 Jan 31;27(1):49-58.

Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Laurent G, Domenichiello AF, Bazinet RP, Dorian P. Docosahexaenoic Acid, But Not Eicosapentaenoic Acid, Supplementation Reduces Vulnerability to Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2012 Oct;5(5):978-83.

Orr SK, Trepanier MO, Bazinet RP.  n-3 Polyunsaturated fatty acids in animal models with neuroinflammation.  Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):97-103.

Arsenault D, Julien C, Chen CT, Bazinet RP, Calon F. Dietary intake of unsaturated fatty acids modulates physiological properties of entorhinal cortex neurons in mice.  J Neurochem. 2012 Jul;122(2):427-43

Ramadeen A, Connelly KA, Leong-Poi H, Hu X, Fujii H, Van Krieken R, Laurent G, Holub BJ, Bazinet RP, Dorian P. N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria. Heart Rhythm. 2012 2012 Jul;9(7):1115-1122.

Trépanier M, Taha AY, Mantha RL, Ciobanu FC, Zeng QH, Tchkhartichvili GM,   Domenichiello AF, Bazinet RP, Burnham WM. Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses.  Epilepsy Research 2012 May;99(3):225-32.

Shi SY, Martin RG, Duncan RE, Choi D, Lu SY, Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K, Wagner KU, Bazinet RP, Woo M. Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against Diet-induced Steatohepatitis and Glucose Intolerance. J Biol Chem. 2012 Mar 23;287(13):10277-88.

Iakoubov R, Ahmed A, Lauffer LM, Bazinet RP, Brubaker PL. Essential Role for Protein Kinase C{zeta} in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat. Endocrinology. 2011 Apr;152(4):1244-52.

Chen CT, Liu Z, Bazinet RP. Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. J Neurochem. 2011 Feb;116(3):363-73.

Honours and Awards

  • Canadian Nutrition Society:  Young Investigator Award for Outstanding Research (2016)
  • Tier II Canada Research Chair in Brain Lipid Metabolism (2013)
  • American Oil Chemists’ Society:  Young Scientist Award (2012)
  • Faculty of Medicine Excellence in Graduate Teaching - Early Career.  University of Toronto (2011)
  • Ontario Ministry of Research and Innovation: Early Researcher Award (2011)
  • International Life Sciences Institute:  Future Leaders Award (2011)
  • Jordi Folch-Pi Early Career Award:  American Society for Neurochemistry (2010)
  • International Society for the Study of Fatty Acids and Lipids:  Early Career Award (2008)
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