Research InterestsMalnutrition; non-alcoholic fatty liver disease.
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Dr. Robert Bandsma received his BSc from the University of Groningen, the Netherlands. He then went on to complete a PhD in Nutrition & Metabolism at the University of Groningen. Dr. Bandsma completed his MD and subspecialty training at the University Medical Center Groningen, the Netherlands, and a Subspecialty Fellowship in the Division of Gastroenterology, Hepatology & Nutrition at the Hospital for Sick Children. He then completed additional training in Tropical Pediatrics from Academic Medical Center, Amsterdam, the Netherlands, and Tropical School of Medicine, Liverpool, United Kingdom. He was an honorary lecturer at the University of Malawi, College of Medicine, and was a staff physician at the Queen Elizabeth Central Hospital, Blantyre Malawi. During his period in Malawi he performed multiple research projects, funded through a postdoctoral research grant. He completed postdoctoral training in the laboratory of Dr. Gary Lewis, Division of Advanced Diagnostics – Metabolism, Toronto General Research Institute. During his postdoctoral fellowship, he received a Canadian Institutes for Health Research (CIHR) postdoctoral fellowship award.
2016 A.S.P.E.N. Rhoads Research Foundation. Identification of severely malnourished children at high risk for death: a metabolomics study.
2015 Medical Research Council. Exploratory observational study of therapeutic feeds to treat intestinal inflammation in Malawian children.
2015 Eat, Play, Think, Catalyst Grant. Centre for Child Nutrition, Health and Development, University of Toronto. Long-term metabolic effects after severe malnnutrition. Principle Investigator.
2015 The Bill and Melinda Gates Foundation. Building the evidence base for appropriate care of the sick, undernourished child in limited resource settings.
2014 Pysicians' Services Incorporated Foundation. Intestinal microbiota, bile acids and NAFLD.
2013 Thrasher Research Fund Operating Grant. Towards improved survival of severely malnourished children: developing improved therapeutic feeds
2013 NASPGHAN Foundation Nestlé Nutrition Research Young Investigator Development Award. Unraveling metabolic dysadaptation in malnutrition: from cellular mechanisms to improved child survival.
Publications and Awards
Kvissberg MA, Dalvi PS, Kerac, Voskujil W, Berkley JA, Priebe MG, Bandsma RH. Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review.Nutr Rev. 2016 Jan;74(1):48-58.
Bandsma RH, Ackerley C, Koulajian K , Zhang l, van Zutphen T, van Dijk TH, Xiao C, Giacca A, Lewis GF. A low protein diet combined with low dose endotoxin is associated with profound changes in glucose metabolism in weaning rats. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E466-73.
Elkadri A, Thoeni C, Deharvengt SJ, Murchie R, Guo C, Stavropoulos JD, Marshall CR, Wales P, Bandsma R, Cutz E, Roifman CM, Chitayat D, Avitzur Y, Stan RV, Muise AM. Mutations in Plasmalemma Vesicle Associated Protein Result in Sieving Protein-Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia. Cell Mol Gastroenterol Hepatol. 2015 Jul;1(4):381-394.
Bandsma RH, van Goor H, Yourshaw M, Horlings RK, Jonkman MF, Schölvinck EH, Karrenbeld A, Scheenstra R, Kömhoff M, Martín MG. Loss of ADAM17 is associated with severe multi-organ dysfunction. Hum Path 2015 Jun;46(6):923-8
Mouzaki M, Bandsma R. Targeting the Gut Microbiota for the Treatment of Non-Alcoholic Fatty Liver Disease. Curr Drug Targets. 2015;16(12):1324-31.
Bandsma RH, Bozic MA, Fridell JA, Crull MH, Molleston J, Avitzur Y, Mozer-Glassberg Y, Gonzalez-Peralta RP, Hodik M, Fecteau A, de Angelis M, Durie P, Ng VL. Simultaneous liver-pancreas transplantation for cystic fibrosis-related liver disease: A multicenter experience. J Cyst Fibros 2014:13(4):471-7.
Bandsma RH, Sokollik C, Chami R, Cutz E, Brubaker PL, Hamilton JK, Perlman K, Zlotkin S, Sigalet DL, Sherman PM, Martin MG, Avitzur Y. From Diarrhea to Obesity in Prohormone Convertase 1/3 Deficiency: Age-dependent Clinical, Pathologic, and Enteroendocrine Characteristics. J Clin Gastroenterol. 2013 47:834-43.
Martín MG, Lindberg I, Solorzano-Vargas RS, Wang J, Avitzur Y, Bandsma R, Sokollik C, Lawrence S, Pickett LA, Chen Z, Egritas O, Dalgic B, Albornoz V, de Ridder L, Hulst J, Gok F, Aydoğan A, Al-Hussaini A, Gok DE, Yourshaw M, Wu SV, Cortina G, Stanford S, Georgia S. Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology 2013 145(1):138-48.
Sokollik C, Bandsma RH, Gana JC, van den Heuvel M, Ling SC. Congenital Portosystemic Shunt: Characterization of A Multi-System Disease. J Pediatr Gastroenterol Nutr. 2013 56:675-81.
Nagasaka H, Yorifuji T, Bandsma RH, Takatani T, Asano H, Mochizuki H, Takuwa M, Tsukahara H, Inui A, Tsunoda T, Hirano K, Miida T, Taguchi T, Miwa I. Sustained high plasma mannose less sensitive to fluctuating blood glucose in glycogen storage disease type Ia children. J. Inher Met Dis. 2013 36:75-81.
Spoelstra MN, Mari A, Mendel M, Senga E, van Rheenen P, van Dijk TH, Reijngoud DJ, Zegers RG, Heikens GT, Bandsma RH. Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic β-cell dysfunction. Metabolism. 2012 61:1224-30.
Moran CJ, Walters TD, Guo CH, Kugathasan S, Klein C, Turner D, Wolters VM, Bandsma RH, Mouzaki M, Zachos M; NEOPICS, Langer JC, Cutz E, Benseler SM, Roifman CM, Silverberg MS, Griffiths AM, Snapper SB, Muise AM. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis. 2012 19:115-123.
Xiao C, Bandsma RH, Dash S, Szeto L, Lewis GF. Exenatide, a Glucagon-like Peptide-1 Receptor Agonist, Acutely Inhibits Intestinal Lipoprotein Production in Healthy Humans. Arterioscler Thromb Vasc Biol. 2012;32:1513-9.
van den Heuvel M, Blencowe H, Mittermayer K, Rylance S, Couperus A, Heikens GT, Bandsma RH. Introduction of bubble CPAP in a teaching hospital in Malawi. Ann Trop Paediatr. 2011;31:59-65.
Song D*, Bandsma RH*, Xiao C, Xi L, Lewis GF. Acute CB1 Receptor Modulation Influences Insulin Sensitivity by an Extra-CNS Effect. Diabetologia 2011;54:1181-1189. * contributed equally to this study.
Xi L, Xiao C, Bandsma RH, Naples M, Adeli K, Lewis GF. C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases. Hepatology 2011;53:127-135.
Bandsma RH, Spoelstra M, Mari A, Mendel M, van Rheenen PF, Senga E, van Dijk T, Heikens GT. Impaired glucose absorption in children with severe malnutrition J Ped. 2010;158:282-287.
Bandsma RH, Mendel M, Spoelstra M, Reijngoud DJ, Boer T, Stellaard F, Brabin B, Schellekens R, Senga E, Heikens GT. Mechanisms behind decreased endogenous glucose production in malnourished children. Pediatr Res. 2010;68:423-428.