Robert G. Josse
Robert JosseMBBS, BSc
Professor
Departments of Medicine and Nutritional Sciences

Contact Info

T. (416) 867-7455

Location

St. Michael's Hospital
61 Queen Street East, 6th Floor
Toronto
ON, M5C 2T2

Accepting

Not accepting new students

Research/Teaching

Research Synopsis:

Often with an emphasis in clinical nutrition, I have obtained peer review and non-peer review grants (mostly phase II and III, pharmaceutically funded multicentre national and international studies) as principal, co-principal or co-investigator. These studies have investigated the effects of various new drugs on diabetes control, hyperlipidemia and prevention, and treatment of diabetes complications. I have been particularly interested in the nutritional management of diabetes with other colleagues in the Department (Jenkins, Wolever) who  promulgated the concept of the glycemic index of foods and the importance of meal frequency as both diabetic and therapeutic principles. Metabolic bone disease research, principally osteoporosis, revolves around phase II and III drug studies for treatment. Much of this work is multinational, multicentre investigations, but I also conduct other epidemiologic and clinical studies in disorders of calcium metabolism and metabolic bone disease.

Publications and Awards

Recent Publications

Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis.

Nigil Haroon N, Szabo E, Raboud JM, Mcdonald-Blumer H, Fung L, Josse RG, Inman RD, Cheung AM.

Arthritis Res Ther. 2015 Dec 24;17(1):377. doi: 10.1186/s13075-015-0873-1.

Effect of Replacing Animal Protein with Plant Protein on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Viguiliouk E, Stewart SE, Jayalath VH, Ng AP, Mirrahimi A, de Souza RJ, Hanley AJ, Bazinet RP, Blanco Mejia S, Leiter LA, Josse RG, Kendall CW, Jenkins DJ, Sievenpiper JL.

Nutrients. 2015 Dec 1;7(12):9804-24. doi: 10.3390/nu7125509.

Recommendations for preventing fracture in long-term care.

Papaioannou A, Santesso N, Morin SN, Feldman S, Adachi JD, Crilly R, Giangregorio LM, Jaglal S, Josse RG, Kaasalainen S, Katz P, Moser A, Pickard L, Weiler H, Whiting S, Skidmore CJ, Cheung AM; Scientific Advisory Council of Osteoporosis Canada.

CMAJ. 2015 Oct 20;187(15):1135-44, E450-61. doi: 10.1503/cmaj.141331. Epub 2015 Sep 14.

Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study.

Schwartz AV, Chen H, Ambrosius WT, Sood A, Josse RG, Bonds DE, Schnall AM, Vittinghoff E, Bauer DC, Banerji MA, Cohen RM, Hamilton BP, Isakova T, Sellmeyer DE, Simmons DL, Shibli-Rahhal A, Williamson JD, Margolis KL.

J Clin Endocrinol Metab. 2015 Nov;100(11):4059-66. doi: 10.1210/jc.2015-1215. Epub 2015 Aug

Bilateral atypical femoral fractures: how much symmetry is there on imaging?

Probyn L, Cheung AM, Lang C, Lenchik L, Adachi JD, Khan A, Josse RG,Tomlinson G, Bleakney R.

Skeletal Radiol. 2015 Nov;44(11):1579-84. doi: 10.1007/s00256-015-2212-7. Epub 2015 Jul 14.

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J, Josse R, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Pencina MJ, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Peterson ED, Holman RR; TECOS Study Group.

N Engl J Med. 2015 Jul 16;373(3):232-42. doi: 10.1056/NEJMoa1501352. Epub 2015 Jun 8.

Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial.

Kennedy CC, Ioannidis G, Thabane L, Adachi JD, Marr S, Giangregorio LM, Morin SN, Crilly RG, Josse RG, Lohfeld L, Pickard LE, van der Horst ML, Campbell G, Stroud J, Dolovich L, Sawka AM, Jain R, Nash L, Papaioannou A.

Trials. 2015 May 12;16:214. doi: 10.1186/s13063-015-0720-3.

Comparison of fracture risk prediction among individuals with reduced and normal kidney function.

Naylor KL, Garg AX, Zou G, Langsetmo L, Leslie WD, Fraser LA, Adachi JD, Morin S, Goltzman D, Lentle B, Jackson SA, Josse RG, Jamal SA.

Clin J Am Soc Nephrol. 2015 Apr 7;10(4):646-53. doi: 10.2215/CJN.06040614. Epub 2015 Feb 5.

Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - comparing site and age-specific risks in women and men.

Prior JC, Langsetmo L, Lentle BC, Berger C, Goltzman D, Kovacs CS, Kaiser SM, Adachi JD, Papaioannou A, Anastassiades T, Towheed T, Josse RG, Brown JP, Leslie WD, Kreiger N; CaMOS Research Group.

Bone. 2015 Feb;71:237-43. doi: 10.1016/j.bone.2014.10.026. Epub 2014 Nov 7.

Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus.

Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw.

J Bone Miner Res. 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. Review.

Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds.

Ramprasath VR, Jenkins DJ, Lamarche B, Kendall CW, Faulkner D, Cermakova L, Couture P, Ireland C, Abdulnour S, Patel D, Bashyam B, Srichaikul K, de Souza RJ, Vidgen E, Josse RG, Leiter LA, Connelly PW, Frohlich J, Jones PJ.

Nutr J. 2014 Oct 18;13:101. doi: 10.1186/1475-2891-13-101.

Intensive blood pressure control, falls, and fractures in patients with type 2 diabetes: the ACCORD trial.

Margolis KL, Palermo L, Vittinghoff E, Evans GW, Atkinson HH, Hamilton BP, Josse RG, O'Connor PJ, Simmons DL, Tiktin M, Schwartz AV.

J Gen Intern Med. 2014 Dec;29(12):1599-606. doi: 10.1007/s11606-014-2961-3. Epub 2014 Aug

Effect of lowering the glycemic load with canola oil on glycemic control and cardiovascular risk factors: a randomized controlled trial.

Jenkins DJ, Kendall CW, Vuksan V, Faulkner D, Augustin LS, Mitchell S, Ireland C, Srichaikul K, Mirrahimi A, Chiavaroli L, Blanco Mejia S, Nishi S, Sahye-Pudaruth S, Patel D, Bashyam B, Vidgen E, de Souza RJ, Sievenpiper JL, Coveney J, Josse RG, Leiter LA.

Diabetes Care. 2014 Jul;37(7):1806-14. doi: 10.2337/dc13-2990. Epub 2014 Jun 14.

Prospectively measured 10-year changes in health-related quality of life and comparison with cross-sectional estimates in a population-based cohort of adult women and men.

Hopman WM, Berger C, Joseph L, Zhou W, Prior JC, Towheed T, Anastassiades T, Adachi JD, Hanley DA, Papadimitropoulos EA, Kirkland S, Kaiser SM, Josse RG, Goltzman D; CaMos Research Group.

Qual Life Res. 2014 Dec;23(10):2707-21. doi: 10.1007/s11136-014-0733-5. Epub 2014 Jun 13.

Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials.

Ha V, Sievenpiper JL, de Souza RJ, Jayalath VH, Mirrahimi A, Agarwal A, Chiavaroli L, Mejia SB, Sacks FM, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM, Vuksan V, Bazinet RP, Josse RG, Beyene J, Kendall CW, Jenkins DJ.

CMAJ. 2014 May 13;186(8):E252-62. doi: 10.1503/cmaj.131727. Epub 2014 Apr 7. Review.

Glucocorticoids predict 10-year fragility fracture risk in a population-based ambulatory cohort of men and women: Canadian Multicentre Osteoporosis Study (CaMos).

Ioannidis G, Pallan S, Papaioannou A, Mulgund M, Rios L, Ma J, Thabane L, Davison KS, Josse RG, Kovacs CS, Kreiger N, Olszynski WP, Prior JC, Towheed T, Adachi JD; CaMos Research Group.

Arch Osteoporos. 2014;9:169. doi: 10.1007/s11657-013-0169-5. Epub 2014 Feb 28.

Fracture risk prediction: importance of age, BMD and spine fracture status.

Krege JH, Wan X, Lentle BC, Berger C, Langsetmo L, Adachi JD, Prior JC, Tenenhouse A, Brown JP, Kreiger N, Olszynski WP, Josse RG, Goltzman D; CaMos Research Group.

Bonekey Rep. 2013 Sep 4;2:404. doi: 10.1038/bonekey.2013.138. eCollection 2013.

Calcium and vitamin D intake and mortality: results from the Canadian Multicentre Osteoporosis Study (CaMos).

Langsetmo L, Berger C, Kreiger N, Kovacs CS, Hanley DA, Jamal SA, Whiting SJ, Genest J, Morin SN, Hodsman A, Prior JC, Lentle B, Patel MS, Brown JP, Anastasiades T, Towheed T, Josse RG, Papaioannou A, Adachi JD, Leslie WD, Davison KS, Goltzman D; CaMos Group.

J Clin Endocrinol Metab. 2013 Jul;98(7):3010-8. doi: 10.1210/jc.2013-1516. Epub 2013 May 23.

Rosiglitazone decreases bone mineral density and increases bone turnover in postmenopausal women with type 2 diabetes mellitus.

Bilezikian JP, Josse RG, Eastell R, Lewiecki EM, Miller CG, Wooddell M, Northcutt AR, Kravitz BG, Paul G, Cobitz AR, Nino AJ, Fitzpatrick LA.

J Clin Endocrinol Metab. 2013 Apr;98(4):1519-28. doi: 10.1210/jc.2012-4018. Epub 2013 Feb 28.

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