Young-In Kim
Young-In KimMD, FRCP(C)
Professor
Departments of Medicine and Nutritional Sciences

Contact Info

T. (416) 847-1750
F. (416) 864-5994

Location

St. Michael's Hospital
30 Bond StreetCC 16-038
Toronto
ON, M5B 1W8

Accepting

Accepting new students

Degree/Qualifications

Postdoctoral Fellowship, Molecular Biology, Department of Cell Biology, Harvard Medical School, Boston, MA
Postdoctoral Fellowship, Nutrition and Cancer, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and Tufts-New England Medical Center, Boston, MA
1992 FRCPC, Gastroenterology, University of Toronto
1990 FRCPC, Internal Medicine, University of Toronto
1987 Doctor of Medicine (MD), University of Toronto

Professional Memberships

2011–present Canadian Nutrition Society
2001–2009 Canadian Society for Clinical Nutrition
1996–present American Association for Cancer Research
1996–present American Gastroenterological Association
1991–present Royal College of Physicians and Surgeons of Canada
1988–present College of Physicians and Surgeons of Ontario
1985–present University of Toronto Chapter of the Alpha Omega AlphaHonor Medical Society
1983–present Ontario Medical Association & Canadian Medical Association

Research/Teaching

Research Synopsis:

My research focuses on several aspects of nutrition (in particular, folate and folic acid ) and cancer (in particular, colon and breast cancers) at the molecular, cellular and translational levels, including prevention, early detection and screening, development and validation of surrogate endpoint biomarkers, molecular genetics and epigenetics, and pharmacogenetics using animal models, cell culture systems and human subjects. More recently, my research program has expanded to investigate the effects of maternal and early life nutrition on epigenetic programming and cancer risk of the offspring.

Publications and Awards

Recent Publications

Sohn KJ, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang YC, Cho RC, Yates Z, Lucock M, Chiang EP, Austin RC, Choi SW, Laird PW, Kim YI. The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification. International Journal of Cancer 124: 1999 – 2005, 2009.

Sie KKY, Chen J, Sohn KJ, Croxford R, Thompson LU, Kim YI.  Folic acid supplementation provided in utero and duration lactation reduces the number of terminal end buds of the developing mammary glands in the offspring. Cancer Letters 280: 72 – 77, 2009.

Kim YI.  Role of the MTHFR polymorphisms in cancer risk modification and treatment response.  Future Oncology 5: 523 – 542, 2009.

Aufreiter S, Gregory JF, Pfeiffer CM, Fazili Z, Kim YI, Marcon N, Kamalaporn P, Pencharz PB, O’Connor DL. Folate is absorbed across the colon of adults: evidence from cecal infusion of 13C-labeled [6S]-5-formyltetrahydrofolic acid. American Journal of Clinical Nutrition 90: 116 – 123, 2009.

Iakoubov R, Lauffer LM, Trivedi S, Kim YI, Brubaker PL.  Carcinogenic effects of exogeneous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice. Endocrinology 150: 4033 – 4043, 2009.

Lindzon GM, Medline A, Sohn KJ, Depeint F, Croxford R, Kim YI. Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci.  Carcinogenesis 30: 1536 – 1543, 2009.

Ly A, Lee H, Chen J, Sie KKY, Renlund R, Medline A, Sohn KJ, Croxford R, Thompson LU, Kim YI.  Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring.  Cancer Research 71: 988-997, 2011.

Sie K, Medline A, van Weel J, Sohn KJ, Croxford R, Kim YI. Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut 2011 (published online May 11, 2011; doi: 10.1136/gut.2011.238782).

Crowell J, Ly A, Kim YI.  Folate and DNA Methylation. In: Maulik N, ed. Nutrition, Epigenetic Mechanims and Human Disease.  CRC Press, Boca Raton, FL: 31-75, 2010.

Ravindran NC, Moskovitz, DN, Kim YI.  The Aging Gut.  In: Chernoff R, ed. Geriatric Nutrition. The Health Professional’s Handbook, 4th ed. Jones and Bartlett Publishers, Inc., Sudbury, MA: 2011 (in press).

 

Honours and Awards

2004    William Goldie Prize and Travel Award for a contribution of notable merit to the advancement of sound knowledge in Internal Medicine, Department of Medicine, University of Toronto

2003    Canadian Association of Gastroenterology Young Investigator Award

2001    Ferring International Gastroenterology Research Award in Inflammatory Bowel Disease Research 

1998    Canada Foundation for Innovation New Opportunities Award (CFI Researcher)

1997    International Life Sciences Institute North America Future Leader Award

Back to Top