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My research focuses on several aspects of nutrition (in particular, folate and folic acid ) and cancer (in particular, colon and breast cancers) at the molecular, cellular and translational levels, including prevention, early detection and screening, development and validation of surrogate endpoint biomarkers, molecular genetics and epigenetics, and pharmacogenetics using animal models, cell culture systems and human subjects. More recently, my research program has expanded to investigate the effects of maternal and early life nutrition on epigenetic programming and cancer risk of the offspring.
Publications and Awards
Sohn KJ, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang YC, Cho RC, Yates Z, Lucock M, Chiang EP, Austin RC, Choi SW, Laird PW, Kim YI. The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification. International Journal of Cancer 124: 1999 – 2005, 2009.
Sie KKY, Chen J, Sohn KJ, Croxford R, Thompson LU, Kim YI. Folic acid supplementation provided in utero and duration lactation reduces the number of terminal end buds of the developing mammary glands in the offspring. Cancer Letters 280: 72 – 77, 2009.
Kim YI. Role of the MTHFR polymorphisms in cancer risk modification and treatment response. Future Oncology 5: 523 – 542, 2009.
Aufreiter S, Gregory JF, Pfeiffer CM, Fazili Z, Kim YI, Marcon N, Kamalaporn P, Pencharz PB, O’Connor DL. Folate is absorbed across the colon of adults: evidence from cecal infusion of 13C-labeled [6S]-5-formyltetrahydrofolic acid. American Journal of Clinical Nutrition 90: 116 – 123, 2009.
Iakoubov R, Lauffer LM, Trivedi S, Kim YI, Brubaker PL. Carcinogenic effects of exogeneous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice. Endocrinology 150: 4033 – 4043, 2009.
Lindzon GM, Medline A, Sohn KJ, Depeint F, Croxford R, Kim YI. Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci. Carcinogenesis 30: 1536 – 1543, 2009.
Ly A, Lee H, Chen J, Sie KKY, Renlund R, Medline A, Sohn KJ, Croxford R, Thompson LU, Kim YI. Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring. Cancer Research 71: 988-997, 2011.
Sie K, Medline A, van Weel J, Sohn KJ, Croxford R, Kim YI. Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut 2011 (published online May 11, 2011; doi: 10.1136/gut.2011.238782).
Crowell J, Ly A, Kim YI. Folate and DNA Methylation. In: Maulik N, ed. Nutrition, Epigenetic Mechanims and Human Disease. CRC Press, Boca Raton, FL: 31-75, 2010.
Ravindran NC, Moskovitz, DN, Kim YI. The Aging Gut. In: Chernoff R, ed. Geriatric Nutrition. The Health Professional’s Handbook, 4th ed. Jones and Bartlett Publishers, Inc., Sudbury, MA: 2011 (in press).
Honours and Awards
2004 William Goldie Prize and Travel Award for a contribution of notable merit to the advancement of sound knowledge in Internal Medicine, Department of Medicine, University of Toronto
2003 Canadian Association of Gastroenterology Young Investigator Award
2001 Ferring International Gastroenterology Research Award in Inflammatory Bowel Disease Research
1998 Canada Foundation for Innovation New Opportunities Award (CFI Researcher)
1997 International Life Sciences Institute North America Future Leader Award