Profile

 

Richard P. Bazinet
Professor
Departments of Nutritional Science
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Ph: 416.946.8276
richard.bazinet@utoronto.ca





Primary Affiliations:

  • Department of Nutritional Sciences

Education/Degrees:

  • BSc, University of Western Ontario;
  • PhD University of Toronto,
  • Post-doctoral fellowship, Brain Physiology and Metabolism Section,
    National Institute on Aging, National Institutes of Health

Awards/Recognition:

  • Faculty of Medicine Excellence in Graduate Teaching - Early Career.  University of Toronto (2011)
  • Early Researcher Award.  Ontario Ministry of Research and Innovation (2011)
  • International Life Sciences Institute.  Future Leaders Award (2011)
  • American Society for Neurochemistry: Jordi Folch-Pi Early Career Award (2010)

  • International Society for the Study of Fatty Acids and Lipids:  Early Career Award (2008)

Professional Memberships:

  • American Society for Neurochemistry
  • American Oil Chemists’ Society
  • Canadian Nutrition Society
  • International Society for the Study of Fatty Acids and Lipids (board member)

Research:

  • The overall goal of my research program is to identify the mechanisms that regulate brain lipid metabolism (signaling) and to identify the role of brain lipid metabolism in the pathogenesis of neurodegenerative diseases and neuropsychiatric disorders. We are currently taking a kinetic and biochemical approach to studying the mechanisms by which dietary polyunsaturated fatty acids regulate the metabolism of arachidonic and docosahexaenoic acids within brain phospholipids.
    We are also investigating the role of dietary polyunsaturated fatty acids in rodent models of neuroinflammation and Alzheimer's disease.                                                 

Recent Publications: (Last 5 years)                                                     

 

  • Iakoubov R, Ahmed A, Lauffer LM, Bazinet RP, Brubaker PL. Essential Role for Protein Kinase C{zeta} in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat. Endocrinology. 2011 Apr;152(4):1244-52.

  • Chen CT, Liu Z, Bazinet RP. Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study. J Neurochem. 2011 Feb;116(3):363-73.

  • Song BJ, Elbert A, Rahman T, Orr SK, Chen CT, Febbraio M, Bazinet RP. Genetic ablation of CD36 does not alter mouse brain polyunsaturated fatty acid concentrations. Lipids. 2010 Apr;45(4):291-9.

  • Orr SK, Tong JYM, Kang JX, Ma DWL, Bazinet RP. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochem Res. 2010 May;35(5):811-9.

  • Boudrault C, Bazinet RP, Kang JX, Ma DW. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochem Int. 2010 Mar;56(4):585-9.

  • Duncan RE, Bazinet RP. Brain arachidonic acid uptake and turnover:  Implications for signaling and the regulation of mood. Curr Opin Clin Nutr Metab Care. 2010 Mar;13(2):130-8.

  • Lee HJ, Bazinet RP, Rapoport SI, Bhattacharjee AK. Brain Arachidonic Acid Cascade Enzymes are Upregulated in a Rat Model of Unilateral Parkinson Disease. Neurochem Res 2010 Apr;35(4):613-9.

  • Bazinet RP. Aspirin, arachidonic acid and the regulation of mood. Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):7-8.

  • Rahman T, Taha AY, Song BJ, Orr SK, Liu Z, Chen CT, Bazinet RP. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations.
    Prostaglandins Leukot Essent Fatty Acids. 2010 February - March;82(2-3):141-145.

  • Grigoriadis S, Barrett J, Pittini R, Herer E, Zaltx A, Bazinet RP, Bradley L, Kennedy S, Steiner M, Levitt A. Omega 3 Supplements in Pregnancy: Are We Too Late to Identify the Possible Benefits? J Obstet Gynaecol Can 2010;32(3):209-216.

  • Crawford MA, Bazinet RP, Sinclair AJ. Fat Intake and CNS Functioning: Ageing and Disease.  Ann Nutr Metab. 2009 Oct;37(Pt 5):1104-9.

  • Bazinet RP. Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder? Biochem Soc Trans. 2009;55(1-3):202-28.

  • Green JT, Liu Z, Bazinet RP. Brain phospholipid arachidonic acid half lives are not altered following 15 weeks of n-3 polyunsaturated fatty acid adequate or deprived diet. J Lipid Res. 2010 Mar;51(3):535-43.

  • Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: an in situ cerebral perfusion study.  Neurochem Int. 2009 Dec;55(7):476-82.

  • Sievenpiper JL, Kendall CW, Esfahani A, Wong JM, Carleton AJ, Jiang HY, Bazinet RP, Vidgen E, Jenkins DJ. Effect of non-oil seed pulses on glycemic control: A meta-analysis of randomized controlled experimental trials in people with and without diabetes. Diabetologia. 2009 Aug;52(8):1479-95.

  • Chen TZ, Liu Z, Ouellet M, Calon F, Bazinet RP.  Rapid -oxidation of eicosapentaenoic acid in mouse brain: An in situ study.  Prostaglandins Leukot Essent Fatty Acids. 2009 Feb-Mar;80(2-3):157-63.

  • Chen TZ, Green JT, Orr SK, Bazinet RP.  Regulation of brain polyunsaturated fatty acid uptake and turnover.  Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):85-91.

  • Milligan LA, Bazinet RP. Evolutionary modifications on human milk composition: evidence from long-chain polyunsaturated fatty acid composition of anthropoid milks. J Hum Evol. 2008 Dec;55(6):1086-95.

  • Taha AY, Chen CT, Liu Z, Kim JH, Mount HT, Bazinet RP. Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor.  Neurochem Res. 2009 Feb;34(2):311-5.

  • Orr SK, Bazinet RP. The emerging role of docosahexaenoic acid in neuroinflammation.  Curr Opin Investig Drugs. 2008 Jul;9(7):735-43.

  • Boudrault C, Bazinet RP, Ma DWL.  Experimental Models and Mechanisms Underlying the Protective Effects of n-3 Polyunsaturated Fatty Acids in Alzheimer's Disease. J Nutr Biochem. 2009 Jan;20(1):1-10. 

  • Bhattacharjee AK, Chang L, Chen M, White L, Bell JM, Bazinet RP and Rapoport SI. Chronic D-amphetamine depresses an imaging marker of arachidonic acid metabolism in rat brain.  Int J Neuropsychopharmacol. 2008 Jun 23:1-13.

  • Rao JS, Lee HJ, Rapoport SI, Bazinet RP. Mode of action of mood stabilizers: Is the arachidonic acid cascade a common target? 2008 Mol Psychiatry. Jun;13(6):585-96.

  • Green JT, Orr SK, Bazinet RP. The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids. J Lipid Res.  2008 May;49(5):939-44.

  • Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI. Imaging apomorphine stimulation of brain arachidonic acid signalling via D2-like receptors in unanesthetized rats.  Psychopharmacology (Berl). 2008 May;197(4):557-66.

  • Lee HJ, Rao JS, Chang L, Rapoport SI, Bazinet RP. Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat. J Lipid Res. 2008 Jan;49(1):162-8.

  • Chen CT, Ma DW, Kim JH, Mount HT, Bazinet RP. The low-density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations.  J Lipid Res. 2008 Jan;49(1):147-52.

  • Lee HJ, Ertley RN, Rapoport SI, Bazinet RP, Rao JS.  Chronic administration of lamotrigine downregulates COX-2 mRNA and protein in rat frontal cortex.  Neurochem Res. 2008 May;33(5):861-6.

  • Milligan LA, Rapoport SI, Cranfield MR, Dittus W, Glander KE, Oftedal OT, Power ML,  Whittier CA, Bazinet RP. Fatty acid composition of wild anthropoid primate milks. Comp Biochem Physiol B Biochem Mol Biol. 2 2008 Jan;149(1):74-82.

  • Lee HJ, Rao JS, Rapoport SI, Bazinet RP.  Antimanic therapies target brain arachidonic acid signaling. Lessons learned about the regulation of brain fatty acid metabolism.  Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):239-46.

  • Vuksan V, Whitham D, Sievenpiper JL, Jenkins AL, Rogovik AL, Bazinet RP, Vidgen E, Hanna A. Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: Results of a randomized controlled trial.  Diabetes Care.  2007 Nov;30(11):2804-10.

  • Bhattacharjee AK, Meister LM, Chang L, Bazinet RP, White L, Rapoport SI. In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease. Neuroimage. 2007 Oct 1;37(4):1112-21.

  • Lee HJ, Rao JS, Chang L, Rapoport SI, Bazinet RP.  Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat:  Implications for the treatment of bipolar disorder. Psychopharmacology (Berl). 2007 Sep;193(4):467-74.

  • Rao JS, Ertley RN, Rapoport SI, Bazinet RP, Lee HJ. Chronic NMDA administration to rats upregulates brain cytosolic phospholipase A2 and its transcription factor, activator protein-2. J Neurochem. 2007 Sep;102(6):1918-27.

  • Rao JS, Bazinet RP, Rapoport SI, Lee HJ. Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-B DNA binding activity and COX-2 mRNA.  Bipolar Disord. 2007 Aug;9(5):513-20.

  • Milligan LA, Bazinet RP. Is docosahexaenoic acid a red herring for the aquatic diet? Br J Nutr. 2007 May;97(5):1023-4.

  • Rao JS, Ertley RN, Demar JC Jr, Rapoport SI, Bazinet RP, Lee HJ. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex.  Mol Psychiatry.  2007 Feb;12(2):151-7.

  • Lee HJ, Rao JS, Ertley RN, Chang L, Rapoport SI, Bazinet RP. Chronic fluoxetine increases cytosolic phospholipase A2 activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat.  Psychopharmacology (Berl). 2007 Jan;190(1):103-15.

  • Rao JS, Ertley RN, Lee HJ, Demar JC Jr, Arnold JT, Rapoport SI, Bazinet RP.  n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.  Mol Psychiatry.  2007 Jan;12(1):36-46.  

  • Bazinet RP, Bhattacharjee AK, Lee HJ. Haloperidol targets brain arachidonic acid signaling. 
    Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):314-5.

  • Rao JS, Bazinet RP, Rapoport SI, Lee HJ. Chronic administration of carbamazepine downregulates AP-2 DNA binding activity and AP-2α protein expression in rat frontal cortex. Biol Psychiatry. 2007 Jan 15;61(2):154-61.

  • Ertley RN, Bazinet RP, Lee HJ, Rapoport SI, Rao JS. Chronic treatment with mood-stabilizers increase membrane GRK3 in rat frontal cortex. Biol Psychiatry. 2007 Jan 15;61(2):246-9.

  • DeMar JC Jr., Lee HJ, Ma K, Chang L, Bell JM, Rapoport SI, Bazinet RP. Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats.  Biochim Biophys Acta. 2006 Sep;1761(9):1050-9.

  • Rao JS, Ertley RN, Lee HJ, Rapoport SI, Bazinet RP. Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex.  Pharmacogenomics J.  2006 Nov-Dec;6(6):413-20.

  • Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI. D-amphetamine stimulates D2 dopamine receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats. J Cereb Blood Flow Metab. 2006 Nov;26(11):1378-88.

  • Bazinet RP, Rao JS, Chang L, Rapoport SI, Lee HJ. Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: Relevance to bipolar disorder. Biol Psychiatry. 2006 Mar 1;59(5):401-7.

  • Bazinet RP, Weis MT, Rapoport SI, Rosenberger TA.  Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: Relevance to bipolar disorder. Psychopharmacology (Berl). 2006 Jan;184(1):122-9.

  • Lee HJ, Mayette J, Rapoport SI and Bazinet RP.  Selective remodeling of cardiolipin fatty acids in the aged rat heart.  Lipids in Health and Disease. 2006 Jan:5(1):2.

  • PubMed

 

 

Address

Department of Nutritional Sciences
Faculty of Medicine
University of Toronto
FitzGerald Building,
150 College Street, Room 306
Toronto, ON, Canada
M5S 3E2