Elena M. Comelli, Ph.D.
Assistant Professor
Departments of Nutritional Sciences

Ph: 416.978.6284
Fax: 416.978.5882


  • My research program focuses on the understanding of the molecular mechanisms regulating intestinal postnatal development. A particular focus is on the establishment of a mature mucus layer and on the role of the intestinal epithelium-gut microbiota crosstalk in this process. We are also evaluating the response of the intestinal ecosystem to probiotic bacteria.                                           

Recent Publications:                                                   


  • Comelli EM, Simmering R, Faure M, Donnicola D, Mansourian R, Rochat F, Corthesy-Theulaz I, Cherbut C. Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota. Genomics. 91(1):70-7, 2008.

  • Wang Y, Holmes E, Comelli EM, Fotopoulos G, Dorta G, Tang H, Rantalainen MJ, Lindon JC, Corthesy-Theulaz I, Fay LB, Kochhar S, Nicholson JK. Topographical variation in metabolic signatures of human gastro-intestinal biopsies revealed by high-resolution magic-angle-spinning 1H-NMR spectroscopy. Journal of Proteome Research, Epub ahead of print 2007 Aug 21.

  • Comelli EM, Sutton-Smith M, Yan Q, Amado M, Panico M, Gilmartin T, Whisenant T, Lanigan CM, Head SR, Goldberg D, Morris HR, Dell A, Paulson JC. Activation of CD4+ and CD8+ lymphocytes leads to dramatic remodeling of N-linked glycans. J. Immunol. 177 (4): 2431-2440, 2006.

  • Comelli EM, Head SR, Gilmartin T, Whisenant T, Haslam SM, North SJ, Wong NK, Kudo T, Narimatsu H, Esko J, Drickamer K, Dell A, Paulson JC. A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology 16 (2): 117-131, 2006.

  • Schumann A, Nutten S, Donnicola D, Comelli EM, Mansourian R, Cherbut C, Corthesy-Theulaz I and Garcia-Rodenas C. Neonatal Antibiotic Treatment Alters Gastrointestinal Tract Developmental Gene Expression and Intestinal Barrier Transcriptome. Physiol. Genomics 23 (2): 235-45, 2005.

  • Amado M, Yan Q, Comelli EM, Collins BE, Paulson JC. PNA high phenotype of activated CD8+ T cells results from de novo synthesis of CD45 glycans. J. Biol. Chem. 279 (35): 36689-97, 2004.

  • Comelli EM, Amado M, Lustig SR, Paulson JC. Identification and expression of Neu4, a novel murine sialidase. Gene 321: 155-161, 2003.

  • Comelli EM, Amado M, Head SR, Paulson JC. Custom microarray for glycobiologists: considerations for glycosyltransferase gene expression profiling. In Glycogenomics: The Impact of Genomics and Informatics on Glycobiology, K. Drickamer and A. Dell eds. 1-8, 2002.

  • Comelli EM, Guggenheim B, Stingele F, Neeser JR. Selection of dairy bacteria strains as probiotics for oral health. Eur. J. Oral Sci. 110 (3): 218-224, 2002.

  • PubMed




Faculty of Medicine
University of Toronto
FitzGerald Building, Room 308A
150 College Street
Toronto ON
M5S 3E2