- ABOUT US
David J.A. Jenkins, M.D., Ph.D., D.Sc.
Canada Research Chair in Nutrition and Metabolism
Department of Nutritional Sciences
Risk Factor Modification Centre, St. Michael's
- The ultimate goal of our research team is to elucidate the potential of diet
to prevent and treat chronic diseases; primarily heart disease, cancer and diabetes.
Our research is clinically based. Dietary trials allow us to also assess
mechanisms in vivo by which diet and/or its components alter risk for disease.
We have spent considerable time assessing the glycemic index of foods, and have
identified legumes and traditional methods of processing as producing a low
glycemic index (eg. white pasta - low vs. white bread - high) We have and
continue to carry out research on vegetable proteins and their potential health
benefits eg. soy, gluten, and other cereal and vegan proteins. Most recently we
have started to combine foods with cholesterol lowering actions (soy, viscous
fibers, oats, barley, plant sterols and nuts - almonds) in a single diet to
lower serum cholesterol.
We have demonstrated that early statin-like effects can be achieved under highly controlled conditions. In the real world this dietary approach has a somewhat dampened level of efficacy, but remains a highly effective dietary approach to cholesterol reduction. We continue to carry out studies on low glycemic index diets, and the quest to find new low glycemic index foods continues. We also work in collaboration with the food industry on a diverse spectrum of food products and food components ranging from macronutrients to phytochemicals.
- Jenkins, DJA. Kendall CWC. Faulkner DA. Nguyen T. Kemp T. Marchie
A. Wong JM. de Souza R. Emam A. Vidgen E. Trautwein EA. Lapsley KG. Holmes
C. Josse RG. Leiter LA. Connelly PW. Singer W. Assessment of the longer-term
effects of a dietary portfolio of cholesterol-lowering foods in
hypercholesterolemia.American Journal of Clinical Nutrition. 83(3):582-91,
- Jenkins, DJA. Kendall CWC. Marchie A. Faulkner DA. Wong JMW. De
Souza R. Emam A. Parker TL. Vidgen E. Trautwein EA. Lapsley KG. Josse RG.
Leiter LA. Singer W. Connelly PW.Direct comparison of a dietary portfolio
of cholesterol-lowering foods with a statin in hypercholesterolemic
participants.American Journal of Clinical Nutrition. Vol. 81(2)(pp
- Jenkins, DJA. Kendall CWC. Marchie A. Faulkner DA. Josse AR. Wong
JMW. de Souza R. Emam A. Parker TL. Li TJ. Josse RG. Leiter LA. Singer W.
Connelly PW. Direct comparison of dietary portfolio vs statin on C-reactive
protein.European Journal of Clinical Nutrition. Vol. 59(7)(pp 851-860),
- Jenkins, DJA. Kendall CW. Marchie A. Faulkner DA. Wong JM. de Souza R. Emam A.
Parker TL. Vidgen E. Lapsley KG. Trautwein EA. Josse RG. Leiter LA. Connelly PW. Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on
serum lipids and C-reactive protein.JAMA. 290(4):502-10, 2003 Jul 23.
- Jenkins, DJA. Kendall CW. D'Costa MA. Jackson CJ. Vidgen E. Singer
W. Silverman JA. Koumbridis G. Honey J. Rao AV. Fleshner N. Klotz L. Soy
consumption and phytoestrogens: effect on serum prostate specific antigen
when blood lipids and oxidized low-density lipoprotein are reduced in
hyperlipidemic men.Journal of Urology. 169(2):507-11, 2003 Feb.
- Jenkins, DJA. Kendall CW. Marchie A. Parker TL. Connelly PW. Qian W.
Haight JS. Faulkner D. Vidgen E. Lapsley KG. Spiller GA. Dose response of
almonds on coronary heart disease risk factors: blood lipids, oxidized
low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric
oxide: a randomized, controlled, crossover trial. Circulation.
106(11):1327-32, 2002 Sep 10.
- Jenkins, DJA. Kendall CWC. Augustin LSA. Martini MC. Axelsen M.
Faulkner D. Vidgen E. Parker T. Lau H. Connelly PW. Teitel J. Singer W.
Vandenbroucke AC. Leiter LA. Josse RG. Effect of wheat bran on glycemic
control and risk factors for cardiovascular disease in type 2 diabetes.Diabetes Care. Vol. 25(9)(pp 1522-1528), 2002.
- Jenkins, DJA. Kendall CW. Jackson CJ. Connelly PW. Parker T. Faulkner D.
Vidgen E. Cunnane SC. Leiter LA. Josse RG. Effects of high- and low-isoflavone
soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in
hyperlipidemic men and women.American Journal of Clinical Nutrition.
76(2):365-72, 2002 Aug.
- Jenkins, DJA. Kendall CW. Connelly PW. Jackson CJ. Parker T. Faulkner D.
Vidgen E. Effects of high- and low-isoflavone (phytoestrogen) soy foods on
inflammatory biomarkers and proinflammatory cytokines in middle-aged men and
women. Metabolism: Clinical & Experimental. 51(7):919-24, 2002 Jul.
- Jenkins, DJA. Kendall CW. Vuksan V. Vidgen E. Parker T. Faulkner D.
Mehling CC. Garsetti M. Testolin G. Cunnane SC. Ryan MA. Corey PN. Soluble
fiber intake at a dose approved by the US Food and Drug Administration for a
claim of health benefits: serum lipid risk factors for cardiovascular
disease assessed in a randomized controlled crossover trial.
American Journal of Clinical Nutrition. 75(5):834-9, 2002 May.
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