Joanne Kotsopoulos MSc, PhD
Associate Professor
Cancer Care Ontario Research Chair in Population Studies, Scientist, Women's College Research Institute, Women’s College Hospital
Dalla Lana School of Public Health and Department of Nutritional Sciences
Joanne Kotsopoulos

Contact Info

T: (416) 351-3732 2126

Location

Women's College Research Institute
76 Grenville St., 6th Floor
Toronto, ON, M5S 1B2

Accepting

Accepting new students

Degree/Qualification

2009 Post-Doctoral Fellow – Channing Laboratory, Brigham & Women’s Hospital/Harvard Medical School – Cancer Epidemiology
2007 PhD, Department of Nutritional Sciences, University of Toronto
2003 MSc, Department of Nutritional Sciences, University of Toronto
1999 HBSc, Human Biology (Specialist Program), University of Toronto

Research Interests

Cancer epidemiology (breast, ovarian), hormones, nutrition, genetics, biomarkers, prevention, prospective cohort studies, case-control studies, hereditary cancer

Dr. Joanne Kotsopoulos is a Scientist with the Familial Breast Cancer Research Unit at the Women’s College Research Institute and an Associate Professor at the Dalla Lana School of Public Health with a cross appointment at the Department of Nutritional Sciences at the University of Toronto (UofT). She received her PhD from the Department of Nutritional Sciences at UofT in 2007 and subsequently conducted her post-doctoral research training at the Brigham and Women’s Hospital/Harvard Medical School. While there, she took part in several studies investigating risk factors for both breast and ovarian cancer using the Nurses’ Health Study Cohorts and had the opportunity to work closely with several experts in nutritional sciences and cancer epidemiology.

Dr. Kotsopoulos returned to Canada as an independent researcher in 2009 as a recipient of a Cancer Care Ontario Chair in Population Studies. More recently she was awarded the Canadian Gene Cure Foundation/CIHR Champion of Genetics Grant and the Canadian Cancer Society Career Development Award in Prevention. Her research program is dedicated at furthering our understanding of BRCA-associated breast and ovarian cancer with the intent of identifying strategies that confer substantial risk reduction and improve outcome. She also leads several projects aimed at improving our understanding of ovarian cancer heterogeneity and at identifying prognostic factors for this highly fatal disease.

She is also actively involved in teaching and mentoring of both undergraduate and graduate student at the University of Toronto.

Research/Teaching

Research Synopsis

Current Research Projects:

  • Identifying modifiable risk factors for hereditary breast and ovarian cancer (reproductive, lifestyle, hormonal).
  • Identifying factors that predict recurrence and outcome in ovarian cancer patients (clinical, genetic, biomarkers).
  • Evaluating the use of circulating markers to predict cancer risk or outcome (sex hormones, circulating tumour DNA).
  • Evaluating the role of genetic and non-genetic factors in a cohort of high-risk, BRCA-negative women.

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Kotsopoulos J, Lubinski J, Gronwald J, Cybulski C, Demsky R, Neuhausen SL, Senter L, Weitzel J, Karlan B, Moller P, Sun P, Narod SA and the Hereditary Breast Cancer Clinical Study Group. Hormone replacement therapy and breast cancer risk in BRCA1 mutation carriers: a case-control study. Breast Cancer Res Treat. 2016 Jan; 155(2):365-73.

Pettapiece-Phillips R*, Kotlyar M*, Chehade R, Salmena L, Narod SA, Akbari M, Jurisica I, Kotsopoulos J. Uninterrupted sedentary behavior downregulates BRCA1 gene expression.  Cancer Prev Res. 2016 Jan;9(1):83-8.IF: 4.444

Kotsopoulos J, Rosen B, Fan  I, McLaughlin JR, Risch HA, May T, Sun P, Narod SA. Ten-year Survival after Epithelial Ovarian Cancer is Not Associated with BRCA Mutation Status Gyn Oncology. 2016 Jan;140(1):42-7. . IF: 3.929

Salmena L, Shaw P, Fan I, Rosen B, Risch HA, McLaughlin JR, Sun P, Narod SA, Kotsopoulos J. Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer. Eur J Gynaecol Oncol. 2015;36(3):260-7. IF: 0.602

Kotsopoulos J, Lubinski J, Gronwald J, Cybulski C, Demsky R, Neuhausen SL, Senter L, Weitzel J, Karlan B, Moller P, Sun P, Narod SA and the Hereditary Breast Cancer Clinical Study Group. Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. Womens Health. 2015 Jul;11(4):453-9. IF: n/a.

Cybulski C, Lubinski J, Huzarski T, Lynch HT, Randall SA, Neuhausen SL, Senter L, Friedman S, Ainsworth P, Singer C, Foulkes WD, Narod SA, Sun P, Kotsopoulos J. Prospective evaluation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2015;151(2):435-41. IF: 4.469

Kotsopoulos  J, Lubinski J, Gronwald J, Cybulski C, Demsky R, Neuhausen SL, Mitchell G, Tung N, Friedman S, Senter L, Weitzel J, Karlan B, Moller P, Sun P, Narod SA and the Hereditary Breast Cancer Clinical Study Group.  Factors Influencing Ovulation and the Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers. Int J Cancer. 2015 Sep;137(5):1136-46. IF: 6.198

Kotsopoulos J, Lubinski J, Salmena L, Lynch HT, Kim-Sing C, Foulkes WD, Ghadirian P, Neuhausen S, Demsky R, Tung N, Ainsworth P, Senter L, Eisen A, Eng C, Singer C, Ginsburg O, Huzarski T, Poll A, Sun P, Narod SA and the Hereditary Breast Cancer Clinical Study Group.  Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers. Breast Cancer Res Treat. 2014;143(3):579-86. IF: 4.469

Back to Top