John Sievenpiper BASc, MD, MSc, PhD, FRCPC
Associate Professor
Department of Nutritional Sciences
John L Sievenpiper

Contact Info

T: (416) 978-5425
F: (416) 978-5882

Location

Medical Sciences Building, 5th Floor, Room 5334A
1 King's College Circle
Toronto, ON, M5S 1A8

Accepting

Pending the availability of funding

Degree/Qualification

FRCPC, Medical Biochemistry, McMaster University
MD, St. Matthew's University School of Medicine
Postdoctoral Fellowship, Nutritional Sciences, University of Toronto
PhD, Nutritional Sciences, University of Toronto
MSc, Nutritional Sciences, University of Toronto

Professional Memberships

Canadian Diabetes Association
American Society of Nutrition
Canadian Association of Medical Biochemists
Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes

Research/Teaching

Research Synopsis

I identify and investigate important diet and disease questions in relation to diabetes and cardiovascular diseases, with the view to inform clinical practice guidelines, public health policy, and the design of future randomized controlled trials. Clinical practice guidelines and public health policy are moving away from traditional nutrient-centric dietary approaches to more food and dietary pattern-based approaches, a process I helped initiate and steer in the Canadian Diabetes Association 2013 Clinical Practice Guidelines for Nutrition Therapy. Through randomized controlled trials, knowledge syntheses (systematic reviews and meta-analyses), and knowledge translation activities, my research program has attempted to be a driver of this modernization investigating the role of dietary sugars, legumes/pulses, tree nuts, and comprehensive dietary patterns in cardiometabolic risk.

Graduate Students

Tauseef Khan (Postdoctoral Fellow)
Stephanie Nishi (PhD candidate)
Vivian Choo (MSc candidate)
Jarvis Noronha (MSc candidate)
Catherine Braunstein (MSc candidate)
Lily Wang (undergraduate research project candidate)
Calvin Won (undergraduate research project candidate)

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Khan TA, Sievenpiper JL. Metabolic improvement with fructose restriction: Is it the fructose or the weight loss? Obesity (Silver Spring). 2016 Feb 9. doi: 10.1002/oby.21431. [Epub ahead of print]

Viguiliouk E, Stewart SE, Jayalath VH, Ng AP, Mirrahimi A, de Souza RJ, Hanley AJ, Bazinet RP, Blanco Mejia S, Leiter LA, Josse RG, Kendall CW, Jenkins DJ, Sievenpiper JL. Effect of Replacing Animal Protein with Plant Protein on Glycemic Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2015;7(12):9804-24.

Jenkins DJ, Jones PJ, Frohlich J, Lamarche B, Ireland C, Nishi SK, Srichaikul K, Galange P, Pellini C, Faulkner D, de Souza RJ, Sievenpiper JL, Mirrahimi A, Jayalath VH, Augustin LS, Bashyam B, Leiter LA, Josse R, Couture P, Ramprasath V, Kendall CW. The effect of a dietary portfolio compared to a DASH-type diet on blood pressure. Nutr Metab Cardiovasc Dis. 2015;25(12):1132-9

Chiavaroli L, de Souza RJ, Ha V, Cozma AI, Mirrahimi A, Wang DD, Yu M, Carleton AJ, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Beyene J, Kendall CW, Jenkins DJ, Sievenpiper JL. Effect of Fructose on Established Lipid Targets: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. J Am Heart Assoc. 2015;4(9):e001700.

Jayalath VH, de Souza RJ, Ha V, Mirrahimi A, Blanco-Mejia S, Di Buono M, Jenkins AL, Leiter LA, Wolever  TM, Beyene J, Kendall CW, Jenkins DJ, Sievenpiper JL. Sugar-sweetened beverage consumption and incident hypertension: a systematic review and meta-analysis of prospective cohorts. Am J Clin Nutr. 2015;102(4):914-21

Wolever TM, Giddens JL, Sievenpiper JL. Effect of ethnicity on glycaemic index: a systematic review and meta-analysis. Nutr Diabetes. 2015 Jul 13;5:e170

Augustin LS, Kendall CW, Jenkins DJ, Willett WC, Astrup A, Barclay AW, Björck I, Brand-Miller JC, Brighenti F, Buyken AE, Ceriello A, La Vecchia C, Livesey G, Liu S, Riccardi G, Rizkalla SW, Sievenpiper JL, Trichopoulou A, Wolever TM, Baer-Sinnott S, Poli A. Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis. 2015;25(9):795-815.

Sievenpiper JL, Tappy L, Brouns F. Fructose as a Driver of Diabetes: An Incomplete View of the Evidence. Mayo Clin Proc. 2015;90(7):984-8.

Choo VL, Sievenpiper JL. The ecologic validity of fructose feeding trials: supraphysiological feeding of fructose in human trials requires careful consideration when drawing conclusions on cardiometabolic risk. Front Nutr. 2015;2:12.

Brown AW, Sievenpiper JL, Kyle TA, Kaiser KA. Communication of randomized controlled trial results must match the study focus. J Nutr. 2015;145(5):1027-9. doi: 10.3945/jn.114.207282

Chiavaroli L, Ha V, de Souza RJ, Kendall CWC, Sievenpiper JL. Overstated associations between fructose and non-alcoholic fatty liver. J Pediatr Gastroenterol Nutr. 2015;60(4):e35.

Chiavaroli L, Ha V, de Souza RJ, Kendall CWC, Sievenpiper JL. Uninterpretable results from a meta-analysis of fructose and metabolic syndrome. Nutrition 2015;31:419-20.

Wolever TMS, Sievenpiper JL. Revised Food Labeling in North America: the Blind Leading the Blind? Eur J Clin Nutr. 2014;68:1275-6

Kahn R, Sievenpiper JL. Dietary Sugar and Body Weight: Have we reached a crisis in the epidemic of obesity and diabetes? We have, but the pox on sugar is overwrought and overworked. Diabetes Care 2014;37:957-62

Ha V, Chiavaroli L, de Souza RJ, Kendall CWC, Sievenpiper JL. Differential association of sugar-sweetened beverages (SSBs) in men and women: is it the sugar or calories? Am J Clin Nutr. 2014;100:1399-400

Chiavaroli L, Ha V, de Souza RJ, Kendall CWC, Sievenpiper JL. Fructose in obesity and cognitive decline: Is it the fructose or the excess energy? Nutr J 2014;13:27.

Chiavaroli L, Ha V, Kendall CWC, Sievenpiper JL. Is industrial fructose just a marker of an unhealthy dietary pattern J Hepatol. 2014;61:172-3.

Blanco Mejia S, Kendall CWC, Viguiliouk E, Augustin LS, Ha V, Cozma AI, Mirrahimi A, Maroleanu A, Chiavaroli L, Leiter LA, de Souza RJ, Jenkins DJA, Sievenpiper JL. Effect of tree nuts on metabolic syndrome criteria: A systematic review and meta-analysis of randomized controlled trials. BMJ Open. 2014;4:e004660

Viguiliouk E, Kendall CWC, Blanco-Mejia S, Cozma AI, Ha V, Mirrahimi M, Jayalath VH, Augustin LS, Chiavaroli L, Leiter LA, de Souza RJ, Jenkins DJA, Sievenpiper JL. The Effect of Tree Nuts on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2014;9:e103376

Li SS, Kendall CWC, de Souza RJ, Jayalath VH, Cozma AI, Ha V, Mirrahimi A, Chiavaroli L, Augustin L, Blanco Mejia S, Leiter LA, Beyene J, Jenkins DJA, Sievenpiper JL. Dietary Pulses, Satiety, and Food Intake: A Systematic Review and Meta-Analysis of Acute Feeding Trials. Intl J Obesity Obesity (Silver Spring). 2014;22:1773-80

Brisbois TD, Marsden SL, Anderson GH, Sievenpiper JL. Estimated intakes and sources of total and added sugars in the Canadian diet. Nutrients. 2014;6:1899-912

Ha V, Chiavaroli L, de Souza RJ, Kendall CWC, Sievenpiper JL. Low sodium but not low fructose improves mtDNA. Exp Clin Endocrinol Diabetes 2014;122:379-80
International Carbohydrate Quality Consortium (ICQC). Glycaemic index: did Health Canada get it wrong? Br J Nutr 2014;111:380-2.

Chiavaroli L, Mirrahimi A, de Souza RJ, Sievenpiper JL. Meta-Analysis of Fructose and Cholesterol: A Concern regarding Missing Data. J Nutr 2014;144:538-9

Mirrahimi A, Chiavaroli L, Srichaikul K, Augustin LS, Sievenpiper JL, Kendall CW, Jenkins DJ. The role of glycemic index and glycemic load in cardiovascular disease and its risk factors: a review of the recent literature. Curr Atheroscler Rep. 2014;16:381.

Sievenpiper JL, de Souza RJ, Cozma AI, Chiavaroli C, Ha V, Mirrahimi A. Fructose vs. glucose and metabolism: do the metabolic differences matter? Curr Opin Lipidol. 2014;25:8-19.

Ha V, Sievenpiper JL, de Souza RJ, Jayalath VH, Mirrahimi A, Chiavaroli L, Di Buono M, Bernstein AM, Leiter LA , Kris-Etherton PM, Vuksan V, Beyene J, Kendall CWC, Jenkins DJA. The Effect of Dietary Pulses on Established Lipid Therapeutic Targets of Cardiovascular Disease: A Systematic Review and Meta-Analysis of controlled feeding trials, CMAJ. 2014;186:E252-62

Jayalath VH, Sievenpiper JL, de Souza RJ, Ha V, Mirrahimi A, Santaren ID, Blanco Mejia S, DiBuono M, Jenkins AL, Leiter LA, Wolever TWS, Beyene J, Kendall CWC, Jenkins DJA. Relation of fructose-containing sugar consumption with risk of hypertension: A systematic review and meta-analysis of prospective cohorts. J Am Coll Nutr 2014;33:328-39

Jenkins DJ, Kendall CW, Vuksan V, Faulkner D, Augustin LS, Mitchell S, Ireland C, Srichaikul K, Mirrahimi A, Chiavaroli L, Blanco Mejia S, Nishi S, Sahye-Pudaruth S, Patel D, Bashyam B, Vidgen E, de Souza RJ, Sievenpiper JL, Coveney J, Josse RG, Leiter LA. Effect of Lowering the Glycemic Load With Canola Oil on Glycemic Control and Cardiovascular Risk Factors: A Randomized Controlled Trial. Diabetes Care. 2014;37:1806-14

Chiu S, Sievenpiper JL, de Souza RJ, Cozma AI, Mirrahimi A, Carleton AJ, DiBuono M, Jenkins AL, Leiter LA, Wolever TWS, Don Wauchope AC, Beyene J, Kendall CWC, Jenkins DJA Effect of fructose on non-alcoholic fatty liver disease (NAFLD): A Systematic Review and Meta-analysis of controlled feeding trials. Eur J Clin Nutr. 2014;68:416-23

Wang DD, Sievenpiper JL, de Souza RJ, Cozma AI, Ha V, Chiavaroli L, Mirrahimi A, Carleton AC, Beyene J, Kendall CWC, Jenkins DJA. Effect of Fructose on Postprandial Triglycerides: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. Atherosclerosis 2014;232:125-133

Gougeon R, Sievenpiper JL, Jenkins D, Yale JF. Bell R, Després JP, Ransom TPP, Camelon K, Dupre J, Kendall C, Hegazi R, Marchetti A, Hamdy O, Mechanick, JI. Transcultural Diabetes Nutrition Algorithm (tDNA): A Canadian perspective. Int J Endocrinol. 2014;2014:151068.

Sievenpiper JL and Dworatzek PDN. Food and dietary pattern based recommendations: An emerging approach to clinical practice guidelines for nutrition therapy in diabetes. Canadian J Diabetes 2013;37:51-57.

Sievenpiper JL, de Souza RJ. Are sugar-sweetened beverages the whole story? Am J Clin Nutr. 2013;98:261-263

Dworatzek PDN, Arcudi K, Gougeon J, Husein N, Sievenpiper JL, Williams S. Nutrition Therapy. In Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian Diabetes Association 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diabetes 2013; 37 (Suppl 1):S45-S55

Cozma AI, Sievenpiper JL. The Role of Fructose, Sucrose, and High-fructose Corn Syrup in Diabetes. U.S. Endocrinology 2013;9:128–38
Ha V, Jayalath VH, Cozma AI, Mirrahimi A, de Souza RJ, Sievenpiper JL. Fructose-containing sugars blood pressure and cardiometabolic risk: A critical review. Curr Hypertens Rep. 2013;15:281-97

Honours and Awards

  • Early Career Excellence in Graduate Teaching and Mentorship Award, 2018
  • PSI Foundation Graham Farquharson Knowledge Translation Fellowship
  • Canadian Diabetes Association Clinician Scientist Award
  • Banting & Best Diabetes Centre Sun Life Financial New Investigator Award
  • CIHR INMD/CNS New Investigator Partnership Prize
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