Young-In Kim

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Other Academic Appointments

Professor, Department of Medicine, University of Toronto

Member, Institute of Medical Sciences, University of Toronto

Attending Physician, Division of Gastroenterology, Department of Medicine, St. Michael’s Hospital

Scientist, Keenan Research Center for Biological Sciences of St. Michael’s Hospital

Research Synopsis

Dr. Young-In Kim's research focuses on several aspects of nutrition and cancer (colorectal, breast and gastric cancers) at the molecular, cellular and translational levels including prevention, early detection and screening, development and validation of surrogate endpoint biomarkers, molecular genetics, epigenetics, pharmacogenetics and nutrigenomics using animal models, cell culture systems and human subjects. His research program integrates epigenetics, molecular and cellular biology, molecular epidemiology, cancer biomarkers and nutritional chemistry and bridges between wet-bench laboratory and translational sciences.

Recent Awards and Distinctions (Selected)

Fellow, The Canadian Association of Gastroenterology (2021)

Clinician Scientist Merit Award, Department of Medicine, University of Toronto (2015)

National and International Committee Memberships (Current)

Research Affairs, Canadian Association of Gastroenterology

Recent Publications

1. Jenkins DJA, Spence JD, Giovannucci EL, Kim YI, Josse RG, Vieth R, Sahye-Pudaruth S, Paquette M, Patel D, Blanco Mejia S, Viguiliouk E, Nishi SK, Kavanagh M, Tsirakis T, Kendall CWC, Pichika SC, Sievenpiper JL. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar. J Am Coll Cardiol. 2021 Feb 2;77(4):423-436. doi: 10.1016/j.jacc.2020.09.619. PMID: 33509399.
2. Plumptre L, Tammen SA, Sohn KJ, Masih SP, Visentin CE, Aufreiter S, Malysheva O, Schroder TH, Ly A, Berger H, Croxford R, Lamers Y, Caudill MA, Choi SW, O'Connor DL, Kim YI. Maternal and Cord Blood Folate Concentrations Are Inversely Associated with Fetal DNA Hydroxymethylation, but Not DNA Methylation, in a Cohort of Pregnant Canadian Women. J Nutr. 2020 Feb 1;150(2):202-211. doi: 10.1093/jn/nxz232. PMID: 31562504.
3. Brosnan JT, Plumptre L, Brosnan ME, Pongnopparat T, Masih SP, Visentin CE, Berger H, Lamers Y, Caudill MA, Malysheva OV, O'Connor DL, Kim YI. Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites. Am J Clin Nutr. 2019 Nov 1;110(5):1131-1137. doi: 10.1093/ajcn/nqz152. PMID: 31350902; PMCID: PMC6821548.
4. Beauchemin CAA, Kim YI, Yu Q, Ciaramella G, DeVincenzo JP. Uncovering critical properties of the human respiratory syncytial virus by combining in vitro assays and in silico analyses. PLoS One. 2019 Apr 15;14(4):e0214708. doi: 10.1371/journal.pone.0214708. PMID: 30986239; PMCID: PMC6464176.
5. Kim SJ, Zhang CXW, Demsky R, Armel S, Kim YI, Narod SA, Kotsopoulos J. Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study. Breast Cancer Res Treat. 2019 Apr;174(3):741-748. doi: 10.1007/s10549-018-05118-3. Epub 2019 Jan 2. PMID: 30603998.
6. Barzilay E, Moon A, Plumptre L, Masih SP, Sohn KJ, Visentin CE, Ly A, Malysheva O, Croxford R, Caudill MA, O'Connor DL, Kim YI, Berger H. Fetal one-carbon nutrient concentrations may be affected by gestational diabetes. Nutr Res. 2018 Jul;55:57-64. doi: 10.1016/j.nutres.2018.04.010. Epub 2018 Apr 21. PMID: 29914628.
7. Jenkins DJA, Spence JD, Giovannucci EL, Kim YI, Josse R, Vieth R, Blanco Mejia S, Viguiliouk E, Nishi S, Sahye-Pudaruth S, Paquette M, Patel D, Mitchell S, Kavanagh M, Tsirakis T, Bachiri L, Maran A, Umatheva N, McKay T, Trinidad G, Bernstein D, Chowdhury A, Correa-Betanzo J, Del Principe G, Hajizadeh A, Jayaraman R, Jenkins A, Jenkins W, Kalaichandran R, Kirupaharan G, Manisekaran P, Qutta T, Shahid R, Silver A, Villegas C, White J, Kendall CWC, Pichika SC, Sievenpiper JL. Supplemental Vitamins and Minerals for CVD Prevention and Treatment. J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584. doi: 10.1016/j.jacc.2018.04.020. PMID: 29852980.
8. Kim YI. Folate and cancer: a tale of Dr. Jekyll and Mr. Hyde? Am J Clin Nutr. 2018 Feb 1;107(2):139-142. doi: 10.1093/ajcn/nqx076. PMID: 29529163.
9. Plumptre L, Masih SP, Sohn KJ, Kim D, Visentin CE, Ly A, Berger H, Croxford R, O'Connor DL, Kim YI. Suboptimal maternal and cord plasma pyridoxal 5' phosphate concentrations are uncommon in a cohort of Canadian pregnant women and newborn infants. Matern Child Nutr. 2018 Jan;14(1):e12467. doi: 10.1111/mcn.12467. Epub 2017 May 24. PMID: 28544455; PMCID: PMC6866191.
10. Kim SJ, Zuchniak A, Sohn KJ, Lubinski J, Demsky R, Eisen A, Akbari MR, Kim YI, Narod SA, Kotsopoulos J. Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study. Am J Clin Nutr. 2016 Sep;104(3):671-7. doi: 10.3945/ajcn.116.133470. Epub 2016 Jul 27. PMID: 27465373.